Purpose

Chromium species in higher oxidation states are toxic and carcinogenic. But lower oxidation state as Cr(III) microelement shows potential antimicrobial properties. Cefoperazone sodium is a parenteral bactericidal third-generation cephalosporin antibiotic effective in treating Pseudomonas bacterial infections. A new drug formed with the complexation of metal and drug. Hence, newer coordinated drugs were explored that can also show the antimicrobial effectiveness similar to free drug.

Methods

cis-[Cr(C₂O₄)₂(H₂O)₂]⁻ was synthesized by the proposed method and its complexation with cefoperazone was done by reflux for 5–6 h with stirring. The structure was characterized by spectroscopic techniques (UV, IR, mass, and AAS). The antimicrobial study was done using agar disk-diffusion method. The interaction of the ligand substitution reaction between cis-[Cr(C₂O₄)₂(H₂O)₂]⁻ and cefoperazone (CFZ) has been investigated in aqueous medium. The reaction has been found to proceed by depending on ligand concentration.

Results

The kinetic reaction was studied at [CFZ] varied from 1.50 × 10⁻² mol dm⁻³ to 4.50 × 10⁻² mol dm⁻³ with pH variation from 3.0 to 5.0. The rate of reaction is found to increase in [H⁺] and [CFZ]. The activation parameters ΔH^# and ΔS^# are found to be 42.72 kJ mol⁻¹ and − 182.41 J K⁻¹ mol⁻¹ respectively. The positive values of activation enthalpy (ΔH^#) shows that the decomposition process is endothermic.

Conclusion

Compared to the free cefoperazone, complexation with chromium(III) metal ion shows similar antimicrobial activity. The reaction takes place through an associative interchange mechanism.

中文翻译：

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水溶液中顺式对二氨基（草酸酯）铬酸盐（III）与头孢哌酮相互作用的动力学和机理：作为抗菌研究

目的

处于较高氧化态的铬物种具有毒性和致癌性。但是作为Cr（III）微量元素的较低氧化态显示出潜在的抗菌性能。头孢哌酮钠是一种肠外杀菌的第三代头孢菌素抗生素，可有效治疗假单胞菌细菌感染。金属和药物络合形成的新药物。因此，探索了新的协调药物，其也显示出与游离药物相似的抗菌效果。

方法

通过所提出的方法合成了顺式[Cr（C ₂ O ₄）₂（H ₂ O）₂ ] ^-，并在搅拌下回流5-6 h与头孢哌酮络合。通过光谱技术（紫外，红外，质谱和原子吸收光谱法）对结构进行了表征。使用琼脂圆盘扩散法进行了抗菌研究。在水介质中研究了顺式[Cr（C ₂ O ₄）₂（H ₂ O）₂ ] ^-与头孢哌酮（CFZ）之间配体取代反应的相互作用。已经发现反应取决于配体浓度而进行。

结果

在[CFZ]下研究了动力学反应，其在1.50×10 ^-2  mol dm ^-3到4.50×10 ^-2  mol dm ^{-3的范围内}，pH在3.0到5.0之间变化。发现[H ⁺ ]和[CFZ]中的反应速率增加。发现活化参数ΔH ^＃和ΔS ^＃分别为42.72 kJ mol ^-1和-18.81 J K ^-1  mol ^-1。活化焓的正值（ΔH ^＃）表明分解过程是吸热的。

结论

与游离头孢哌酮相比，与铬（III）金属离子的络合显示出相似的抗菌活性。该反应通过缔合交换机制发生。