In this study, at first, gold nanorods (GNRs) were synthesized and then they were coated with a layer of hydrogel composed of poly(N-isopropylacrylamide) (PNIPAM) grafted onto carboxymethyl cellulose (CMC) as a backbone. The chemical structure of GNRs/PNIPAM-g-CMC hydrogel was characterized by Fourier transform infrared (FT-IR), thermogravimetric analysis (TGA), atomic-force microscopy (AFM), transmission electron microscopy (TEM), and scanning electron microscopy (SEM). The swelling properties of the obtained GNRs/PNIPAM-g-CMC hydrogel were studied at different times and temperatures. In addition, drug release from doxorubicin-loaded GNRs/PNIPAM-g-CMC hydrogel was examined at different temperatures during time. The drug release mechanism was studied by first-order, second-order, and Ritger–Peppas models. Finally, the GNRs/PNIPAM-g-CMC hydrogel biocompatibility was tested against L929 mouse fibroblast cells by 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) method. Our study suggests that GNRs coated with low-cost hydrogels can be excellent candidate for drug delivery systems.

中文翻译：

---

开发新型热响应水凝胶涂层金纳米棒作为药物递送系统

在这项研究中，首先合成了金纳米棒（GNRs），然后将它们涂上一层由接枝到羧甲基纤维素（CMC）作为骨架的聚（N-异丙基丙烯酰胺）（PNIPAM）组成的水凝胶。GNRs/PNIPAM-g-CMC水凝胶的化学结构通过傅里叶变换红外（FT-IR）、热重分析（TGA）、原子力显微镜（AFM）、透射电子显微镜（TEM）和扫描电子显微镜（扫描电镜）。在不同时间和温度下研究了所得 GNRs/PNIPAM-g-CMC 水凝胶的溶胀性能。此外，在不同温度下检查了载有阿霉素的 GNRs/PNIPAM-g-CMC 水凝胶的药物释放。通过一阶、二阶和 Ritger-Peppas 模型研究药物释放机制。最后，通过 3-[4,5-二甲基噻唑-2-基]-2,5 二苯基溴化四唑 (MTT) 方法测试了 GNRs/PNIPAM-g-CMC 水凝胶对 L929 小鼠成纤维细胞的生物相容性。我们的研究表明，涂有低成本水凝胶的 GNR 可以成为药物递送系统的绝佳候选者。