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Development of a novel thermo-responsive hydrogel-coated gold nanorods as a drug delivery system
Gold Bulletin ( IF 2.1 ) Pub Date : 2018-12-08 , DOI: 10.1007/s13404-018-0248-x
Mehran Kurdtabar , Gazal Baghestani , Ghasem Rezanejade Bardajee

In this study, at first, gold nanorods (GNRs) were synthesized and then they were coated with a layer of hydrogel composed of poly(N-isopropylacrylamide) (PNIPAM) grafted onto carboxymethyl cellulose (CMC) as a backbone. The chemical structure of GNRs/PNIPAM-g-CMC hydrogel was characterized by Fourier transform infrared (FT-IR), thermogravimetric analysis (TGA), atomic-force microscopy (AFM), transmission electron microscopy (TEM), and scanning electron microscopy (SEM). The swelling properties of the obtained GNRs/PNIPAM-g-CMC hydrogel were studied at different times and temperatures. In addition, drug release from doxorubicin-loaded GNRs/PNIPAM-g-CMC hydrogel was examined at different temperatures during time. The drug release mechanism was studied by first-order, second-order, and Ritger–Peppas models. Finally, the GNRs/PNIPAM-g-CMC hydrogel biocompatibility was tested against L929 mouse fibroblast cells by 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) method. Our study suggests that GNRs coated with low-cost hydrogels can be excellent candidate for drug delivery systems.

中文翻译:

开发新型热响应水凝胶涂层金纳米棒作为药物递送系统

在这项研究中,首先合成了金纳米棒(GNRs),然后将它们涂上一层由接枝到羧甲基纤维素(CMC)作为骨架的聚(N-异丙基丙烯酰胺)(PNIPAM)组成的水凝胶。GNRs/PNIPAM-g-CMC水凝胶的化学结构通过傅里叶变换红外(FT-IR)、热重分析(TGA)、原子力显微镜(AFM)、透射电子显微镜(TEM)和扫描电子显微镜(扫描电镜)。在不同时间和温度下研究了所得 GNRs/PNIPAM-g-CMC 水凝胶的溶胀性能。此外,在不同温度下检查了载有阿霉素的 GNRs/PNIPAM-g-CMC 水凝胶的药物释放。通过一阶、二阶和 Ritger-Peppas 模型研究药物释放机制。最后,通过 3-[4,5-二甲基噻唑-2-基]-2,5 二苯基溴化四唑 (MTT) 方法测试了 GNRs/PNIPAM-g-CMC 水凝胶对 L929 小鼠成纤维细胞的生物相容性。我们的研究表明,涂有低成本水凝胶的 GNR 可以成为药物递送系统的绝佳候选者。
更新日期:2018-12-08
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