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Development of a novel thermo-responsive hydrogel-coated gold nanorods as a drug delivery system

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Abstract

In this study, at first, gold nanorods (GNRs) were synthesized and then they were coated with a layer of hydrogel composed of poly(N-isopropylacrylamide) (PNIPAM) grafted onto carboxymethyl cellulose (CMC) as a backbone. The chemical structure of GNRs/PNIPAM-g-CMC hydrogel was characterized by Fourier transform infrared (FT-IR), thermogravimetric analysis (TGA), atomic-force microscopy (AFM), transmission electron microscopy (TEM), and scanning electron microscopy (SEM). The swelling properties of the obtained GNRs/PNIPAM-g-CMC hydrogel were studied at different times and temperatures. In addition, drug release from doxorubicin-loaded GNRs/PNIPAM-g-CMC hydrogel was examined at different temperatures during time. The drug release mechanism was studied by first-order, second-order, and Ritger–Peppas models. Finally, the GNRs/PNIPAM-g-CMC hydrogel biocompatibility was tested against L929 mouse fibroblast cells by 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) method. Our study suggests that GNRs coated with low-cost hydrogels can be excellent candidate for drug delivery systems.

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Funding

This work was funded by the Karaj Islamic Azad University, PNU, and INSF.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Islamic Azad University, Karaj Branch, PO BOX 31485-313, Karaj, Iran

    Mehran Kurdtabar & Gazal Baghestani

  2. Department of Chemistry, Payame Noor University, PO BOX 19395-3697, Tehran, Iran

    Ghasem Rezanejade Bardajee

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  1. Mehran Kurdtabar
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  2. Gazal Baghestani
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  3. Ghasem Rezanejade Bardajee
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Correspondence to Mehran Kurdtabar or Ghasem Rezanejade Bardajee.

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Kurdtabar, M., Baghestani, G. & Bardajee, G.R. Development of a novel thermo-responsive hydrogel-coated gold nanorods as a drug delivery system. Gold Bull 52, 9–17 (2019). https://doi.org/10.1007/s13404-018-0248-x

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  • DOI: https://doi.org/10.1007/s13404-018-0248-x

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