Microphysiological systems (MPS), also known as organ-on-a-chip technology, combine cell culture models and microtechnology to mimic tissue microenvironment and provide improved physiological relevance of in vitro model systems. The unique advantage of MPS technology is manifested where multiple organs interact through complex mechanisms. Multi-organ MPS, or body-on-a-chip systems, aim to recapitulate organ interactions and provide a model of the whole body. Combination of the state-of-the-art microtechnology and mathematical modeling platforms to design and interpret multi-organ systems has contributed to the development of novel MPS for testing drugs and modeling diseases. Here, we summarize recent progress in the development of MPS, with emphasis on multi-organ MPS combined with mathematical models.

中文翻译：

---

用微生理系统（MPS）模仿人类生理

微生理系统（MPS），也称为片上器官技术，结合了细胞培养模型和微技术来模仿组织的微环境，并改善了体外模型系统的生理相关性。MPS技术的独特优势体现在多个​​器官通过复杂机制相互作用的地方。多器官MPS或片上身体系统旨在概述器官相互作用并提供整个身体的模型。先进的微技术和数学建模平台相结合来设计和解释多器官系统，为开发用于测试药物和建模疾病的新型MPS做出了贡献。在这里，我们总结了MPS开发的最新进展，重点是结合数学模型的多器官MPS。