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Mimicking the Human Physiology with Microphysiological Systems (MPS)

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Abstract

Microphysiological systems (MPS), also known as organ-on-a-chip technology, combine cell culture models and microtechnology to mimic tissue microenvironment and provide improved physiological relevance of in vitro model systems. The unique advantage of MPS technology is manifested where multiple organs interact through complex mechanisms. Multi-organ MPS, or body-on-a-chip systems, aim to recapitulate organ interactions and provide a model of the whole body. Combination of the state-of-the-art microtechnology and mathematical modeling platforms to design and interpret multi-organ systems has contributed to the development of novel MPS for testing drugs and modeling diseases. Here, we summarize recent progress in the development of MPS, with emphasis on multi-organ MPS combined with mathematical models.

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Acknowledgements

This work was supported by Ministry of Trade, Industry and Energy (MOTIE), Korea (10050154, Establishment of Infrastructure for industrialization of Korean Useful Microbes, R0004073), National Research Foundation of Korea (2016R1D1A1B03934710), and Hongik University Research Fund. This work was also partly supported by NIH (grant # R44TR001326 and U01CA214300). Authors have no conflict of interest to declare.

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Authors and Affiliations

  1. Department of Chemical Engineering, Hongik University, 94, Wausan-ro, Mapo-gu, Seoul, 04066, Korea

    Jong Hwan Sung & Jamin Koo

  2. Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, 14853, USA

    Michael L. Shuler

  3. Hesperos, Inc., Orlando, FL, 32836, USA

    Michael L. Shuler

  4. Robert Frederick Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, 14853, USA

    Michael L. Shuler

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  1. Jong Hwan Sung
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  2. Jamin Koo
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Correspondence to Jong Hwan Sung or Michael L. Shuler.

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Sung, J.H., Koo, J. & Shuler, M.L. Mimicking the Human Physiology with Microphysiological Systems (MPS). BioChip J 13, 115–126 (2019). https://doi.org/10.1007/s13206-019-3201-z

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