Flow lithography in a conventional rectangular microchannel is limited to fabrication of particles for which only the shapes of top perimeters are controlled. We present a flow lithography technique for fabrication of microparticles of diverse 3D shapes and multiple layers using non-rectangular microchannels with designed cross sections that allow the creation of complex shapes and diverse cross-sectional shapes. Variations in cross-sectional shape allow high-throughput, on-demand production of microparticles in unconventional shapes such as tetrahedrons and pyramids. Multilayered 3D particles were generated in an enlarging triangular channel combined with on-chip PDMS valves, which allow particle alignment and fluid exchange. These 3D microparticles are expected to further expand the wide variety of applications of microparticles, especially in drug delivery and tissue engineering fields.

中文翻译：

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在具有非矩形横截面的微通道中生成3D微粒

常规矩形微通道中的流式光刻技术限于仅控制顶部周边形状的颗粒的制造。我们提出了一种使用非矩形微通道制造具有不同3D形状和多层微粒的流式光刻技术，该非矩形微通道的设计截面允许创建复杂的形状和不同的截面形状。横截面形状的变化允许高通量按需生产非常规形状的微粒，例如四面体和金字塔。多层3D颗粒是在扩大的三角形通道中与片上PDMS阀组合产生的，从而允许颗粒对齐和流体交换。这些3D微粒有望进一步扩展微粒的广泛应用，