In recent times, about 35% of patients suffered from post laparotomy wound dehiscence and the effective management of wound is highly inevitable. Natural polymers such as chitosan and dextran have excellent biodegradability and biocompatibility. These features make them an ideal candidate for biomedical applications. The present study is aimed to synthesize curcumin loaded chitosan/dextran nanocomposite and to evaluate its antibacterial and abdominal wound healing properties. The curcumin loaded chitosan/dextran nanocomposite was characterized by UV–vis spectroscopy, X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM) and Zeta potential. FTIR results inferred the strong interaction between the three components. The surface morphology of curcumin loaded chitosan/dextran nanocomposite was spherical shaped which are firmly anchored on the polymer matrix. TEM analysis also confirmed the formation of the composite. The XRD analysis confirmed the presence of crystalline material. The curcumin loaded chitosan/dextran nanocomposite recorded greater antibacterial effects on S. mutans and E. coli. The number of dead bacterial cells was significantly higher in curcumin loaded chitosan/dextran nanocomposite. Moreover, curcumin loaded chitosan/dextran nanocomposite stimulated the regeneration of new tissues and promoted the wound healing efficiency in the mouse. Therefore, the developed materials have a potential role as antimicrobial and abdominal wound healing in biomedical fields.

中文翻译：

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姜黄素负载壳聚糖/右旋糖酐纳米复合材料的新方法治疗复杂的腹部伤口裂开。

近年来，大约35％的患者在剖腹手术后出现伤口裂开，并且伤口的有效处理是不可避免的。天然聚合物如壳聚糖和葡聚糖具有出色的生物降解性和生物相容性。这些功能使其成为生物医学应用的理想选择。本研究旨在合成负载姜黄素的壳聚糖/葡聚糖纳米复合材料，并评估其抗菌和腹部伤口愈合特性。姜黄素负载的壳聚糖/葡聚糖纳米复合材料的特征在于紫外可见光谱，X射线衍射（XRD），傅立叶变换红外（FTIR）光谱，扫描电子显微镜（SEM），透射电子显微镜（TEM）和Zeta电位。FTIR结果推断出这三个成分之间的强相互作用。姜黄素负载的壳聚糖/葡聚糖纳米复合材料的表面形态为球形，牢固地锚固在聚合物基质上。TEM分析也证实了复合物的形成。XRD分析证实了结晶物质的存在。载有姜黄素的壳聚糖/葡聚糖纳米复合材料对细菌的抗菌作用更大变形链球菌和大肠杆菌。载有姜黄素的壳聚糖/葡聚糖纳米复合材料中死细菌细胞的数量显着更高。此外，姜黄素负载的壳聚糖/葡聚糖纳米复合材料刺激了新组织的再生，并提高了小鼠的伤口愈合效率。因此，开发的材料在生物医学领域具有抗菌和腹部伤口愈合的潜在作用。