Abstract

Background

In the medicolegal literature, focal concavities or notching of the corpus callosum has been thought to be associated with fetal alcohol spectrum disorders. Recent work suggests corpus callosum notching is a dynamic and normal anatomical feature, although it has not yet been defined in early life or infancy.

Objective

Our purpose was to characterize the dorsal contour of the corpus callosum during the first 2 years of life by defining the prevalence, onset and trajectory of notching on midsagittal T1-weighted images.

Materials and methods

We reviewed retrospectively 1,157 consecutive patients between birth and 2 years of age. Corpus callosum morphology was evaluated and described. A notch was defined as a dorsal concavity of at least 1 mm in depth along the dorsal surface of the corpus callosum. Patient age as well as notch depth, location, number and presence of the pericallosal artery in the notch were noted.

Results

Two hundred thirty-three notches were identified in 549 patients: 36 anterior, 194 posterior and 3 patients with undulations. A statistically significant (R²=0.53, Beta=0.021, P=0.002) positive correlation between posterior notch prevalence and age in months was noted. A positive correlation between age and depth of the posterior notch was also statistically significant (r=0.32, n=179, P≤0.001). A trend for increased anterior notch prevalence with age was identified with significant correlation between visualized pericallosal artery indentation and anterior notching (r=0.20, n=138, P=0.016). Sub-analysis of the first month of life showed corpus callosum notching was not present.

Conclusion

The presence of posterior notching increased significantly with age and was more frequent than that of anterior notching. Corpus callosum notching was absent in the first week of life, building on prior studies suggesting corpus callosum notching is acquired. This study provides baseline data on normative corpus callosum notching trajectories by age group during early life, a helpful correlate when associating corpus callosum morphology with disease.

中文翻译：

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生命头两年的during体背侧轮廓的形态变化。

摘要

背景

在法医学文献中，focal的局灶性凹陷或凹口被认为与胎儿酒精谱疾病有关。最近的工作表明call体切口是一种动态且正常的解剖特征，尽管在生命早期或婴儿期尚未定义。

目的

我们的目的是通过定义矢状T1加权中位图像上切口的发生率，发作和轨迹来表征生命的头2年内first体的背侧轮廓。

材料和方法

我们回顾性分析了出生至2岁之间的1,157例连续患者。评价和描述了call体形态。切口定义为沿call体背表面深度至少1 mm的背凹。记录患者的年龄以及切口深度，切口的位置，数量和椎旁动脉的存在。

结果

在549例患者中鉴定出233个切口：前36例，后194例和3例起伏。注意到后切口患病率与月龄之间有统计学意义（R ² = 0.53，Beta = 0.021，P = 0.002）正相关。后侧凹口的年龄和深度之间的正相关性有统计学显著（[R = 0.32，Ñ = 179，P ≤0.001）。可见随着年龄的增长，前切口的患病率呈增加趋势，并且与可视化的腓肠动脉压痕和前切口之间存在显着相关性（r = 0.20，n = 138，P= 0.016）。生命第一个月的亚分析显示不存在call体切口。

结论

后切口的存在随着年龄的增长而显着增加，并且比前切口的出现频率更高。在先前的研究表明获得acquired体not陷的基础上，在生命的第一周内没有call体切口。这项研究提供了按年龄段划分的早期early体标准化体切迹轨迹的基线数据，这是将体形态与疾病相关联的有用关联。