Purpose

To compare the polymerization time of n-butyl cyanoacrylate (NBCA) and lipiodol mixture in a static model and a pulsating flow model simulating embolization procedure of small caliber arteries.

Materials and Methods

The polymerization time of NBCA–lipiodol mixture was measured by the morphological changes of a glue droplet in a petri dish. For the flow model, we used a 2-mm-inner-diameter polyvinyl alcohol tube connected to a pulsation pump. Bovine serum was supplied from the pump and circulated into the system at 30 ml/min and 60 bpm. A 0.64-mm-inner-diameter silicon microcatheter was inserted into this system, and then, 0.5 ml of glue was injected into the tube. The flow cessation time was defined as the time it took to stop the serum draining from the end of the tube. Six samples of 100, 66, 50, 40, 33, and 20 vol% NBCA were assessed.

Results

The median polymerization times for each concentration were 0.12, 3.72, 12.30, 27.41, 57.68, and 63.67 s, respectively. The median flow cessation times were 0.28, 0.78, 1.43, 3.75, 4.50, and 9.29 s, respectively. The flow cessation time was significantly shorter than the polymerization time for all samples except for 100 vol% cyanoacrylate (p < 0.05).

Conclusion

The flow cessation time of cyanoacrylate glue was significantly shorter than the polymerization time in an in vitro experiment. The injected glue possibly stops the blood flow before the completion of polymerization in the vascular system.

中文翻译：

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停止血流是否比氰基丙烯酸正丁酯-脂质体混合物的聚合反应快？体外幻影研究

目的

在静态模型和模拟小口径动脉栓塞过程的脉动模型中比较氰基丙烯酸正丁酯（NBCA）和碘醇混合物的聚合时间。

材料和方法

NBCA-碘油混合物的聚合时间通过培养皿中胶滴的形态变化来测量。对于流量模型，我们使用了一个2毫米内径的聚乙烯醇管，该管与脉动泵相连。从泵提供牛血清，并以30 ml / min和60 bpm的速度循环进入系统。将0.64mm内径的硅微导管插入该系统中，然后将0.5 ml胶水注入该管中。停止流的时间定义为停止血清从试管末端排出所需的时间。评估了100、66、50、40、33和20 vol％NBCA的六个样品。

结果

每个浓度的中值聚合时间分别为0.12、3.72、12.30、27.41、57.68和63.67 s。中位流停止时间分别为0.28、0.78、1.43、3.75、4.50和9.29 s。除100％（体积）氰基丙烯酸酯外，所有样品的停止流动时间均明显短于聚合时间（p  <0.05）。

结论

在体外实验中，氰基丙烯酸酯胶的停止流动时间明显短于聚合时间。注入的胶水可能会在血管系统中的聚合反应完成之前停止血液流动。