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Is the Cessation of Blood Flow Faster than the Polymerization of an n-Butyl Cyanoacrylate–Lipiodol Mixture? An In Vitro Phantom Study

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Abstract

Purpose

To compare the polymerization time of n-butyl cyanoacrylate (NBCA) and lipiodol mixture in a static model and a pulsating flow model simulating embolization procedure of small caliber arteries.

Materials and Methods

The polymerization time of NBCA–lipiodol mixture was measured by the morphological changes of a glue droplet in a petri dish. For the flow model, we used a 2-mm-inner-diameter polyvinyl alcohol tube connected to a pulsation pump. Bovine serum was supplied from the pump and circulated into the system at 30 ml/min and 60 bpm. A 0.64-mm-inner-diameter silicon microcatheter was inserted into this system, and then, 0.5 ml of glue was injected into the tube. The flow cessation time was defined as the time it took to stop the serum draining from the end of the tube. Six samples of 100, 66, 50, 40, 33, and 20 vol% NBCA were assessed.

Results

The median polymerization times for each concentration were 0.12, 3.72, 12.30, 27.41, 57.68, and 63.67 s, respectively. The median flow cessation times were 0.28, 0.78, 1.43, 3.75, 4.50, and 9.29 s, respectively. The flow cessation time was significantly shorter than the polymerization time for all samples except for 100 vol% cyanoacrylate (p < 0.05).

Conclusion

The flow cessation time of cyanoacrylate glue was significantly shorter than the polymerization time in an in vitro experiment. The injected glue possibly stops the blood flow before the completion of polymerization in the vascular system.

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Acknowledgements

This work was supported by JSPS KAKENHI Grant Number JP16K19841.

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Author notes

  1. Natsuko Hayashi

    Present address: Department of Radiology, Osaka General Hospital of West Japan Railway Company, 1-2-22 Matsuzakicho, Abeno-ku, Osaka, 5450053, Japan

Authors and Affiliations

  1. Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajiicho, Kawaramachi Hirokoji, Kamigyo-ku, Kyoto, 6028566, Japan

    Natsuko Hayashi, Hiroshi Miura, Toshiyuki Okamoto, Shunsuke Asai, Koji Sakai, Tatsuya Hirota & Kei Yamada

  2. Department of Radiology, Fukuchiyama City Hospital, 231 Atsunakacho, Fukuchiyama, Kyoto, 6208505, Japan

    Yoshito Takeuchi

  3. Institute for Materials Chemistry and Engineering, Kyusyu University, CE41, 744 Motooka, Nishi-ku, Fukuoka, 8190395, Japan

    Yusuke Arima

  4. Graduate School of Health Care Sciences, Jikei Institute, 1-2-8 Miyahara, Yodogawa-ku, Osaka, 5320003, Japan

    Mitsuaki Toda

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  1. Natsuko Hayashi
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Correspondence to Yoshito Takeuchi.

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Hayashi, N., Takeuchi, Y., Miura, H. et al. Is the Cessation of Blood Flow Faster than the Polymerization of an n-Butyl Cyanoacrylate–Lipiodol Mixture? An In Vitro Phantom Study. Cardiovasc Intervent Radiol 43, 630–635 (2020). https://doi.org/10.1007/s00270-019-02393-5

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  • DOI: https://doi.org/10.1007/s00270-019-02393-5

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