In this work, a novel free AgNPs composite, St-A-E/M, and nanocomposite beads, St-A-E/M-Ag, as a novel drug carrier were successfully prepared and used as controlled-release drug delivery systems for methyl prednisolone as a model drug. The structure of the resulted materials was identified using UV–Vis, SEM, EDX, XRD, FTIR, TEM, DLS, AFM and TGA/DTG spectroscopic techniques. The TEM and DLS results demonstrated that the incorporated AgNPs in the polymer matrix were spherical with diameters ranging from 50 to 111 nm. The influence of contact time, temperature, content of initial pH and Ag nanoparticles on the load and release behaviors of drug model was investigated under static conditions. The results indicated that the % release of drug model from the nanocomposite in different amounts of AgNPs was rather higher in comparison with the corresponding free-NPs composite. On the other hand, the results showed that the % release of drug increased by the increase in AgNPs content until 3.3% (V/V) in the polymer matrix, whereas that released beyond it was decreased. The maximum of release was also found within 9 h and at pH 7.4 for the nanocomposite. Furthermore, different release kinetic was employed for the description of the release process. Also, the nanocomposite exhibited higher antibacterial activity compared to the corresponding free-NPs composite.

中文翻译：

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基于淀粉作为药物传递系统的 pH 敏感游离 AgNPs 复合物和纳米复合珠

在这项工作中，成功制备了一种新型游离 AgNPs 复合物 St-AE/M 和纳米复合珠 St-AE/M-Ag 作为新型药物载体，并将其用作甲基强的松龙的控释给药系统。模型药。使用 UV-Vis、SEM、EDX、XRD、FTIR、TEM、DLS、AFM 和 TGA/DTG 光谱技术鉴定所得材料的结构。TEM 和 DLS 结果表明聚合物基质中掺入的 AgNPs 是球形的，直径范围为 50 到 111 nm。在静态条件下研究了接触时间、温度、初始pH值和Ag纳米颗粒对药物模型负载和释放行为的影响。结果表明，与相应的游离 NPs 复合材料相比，不同量的 AgNPs 纳米复合材料的药物模型释放百分比相当高。另一方面，结果表明药物的释放百分比随着 AgNPs 含量的增加而增加，直到聚合物基质中的 3.3% (V/V)，而超过它的释放量减少。纳米复合材料的最大释放量也在 9 小时内和 pH 7.4 下发现。此外，使用不同的释放动力学来描述释放过程。此外，与相应的游离 NPs 复合材料相比，纳米复合材料表现出更高的抗菌活性。而超出它的释放量减少了。纳米复合材料的最大释放量也在 9 小时内和 pH 7.4 下发现。此外，使用不同的释放动力学来描述释放过程。此外，与相应的游离 NPs 复合材料相比，纳米复合材料表现出更高的抗菌活性。而超出它的释放量减少了。纳米复合材料的最大释放量也在 9 小时内和 pH 7.4 下发现。此外，使用不同的释放动力学来描述释放过程。此外，与相应的游离 NPs 复合材料相比，纳米复合材料表现出更高的抗菌活性。