The development of a flow chemistry approach to the anti-fungal fluconazole is described. A continuous, two-reactor, three-step synthesis of fluconazole from 2-chloro-2′,4′-difluoroacetophenone was achieved with no intermediate purification. The synthesis has been successfully demonstrated on a Vapourtec commercial flow chemistry system.

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中文翻译：

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氟康唑的多步连续流合成

描述了抗真菌氟康唑的流化学方法的发展。从2-氯-2'，4'-二氟苯乙酮连续，两反应器，三步合成氟康唑，无需中间纯化。该合成已在Vapourtec商业流化学系统上成功证明。

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