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Multi-step continuous flow synthesis of fluconazole
Journal of Flow Chemistry ( IF 2.0 ) Pub Date : 2018-12-06 , DOI: 10.1007/s41981-018-0019-0 Judy Szeto , Vi-Anh Vu , Jeremiah P. Malerich , Nathan Collins
中文翻译:
氟康唑的多步连续流合成
更新日期:2018-12-06
Journal of Flow Chemistry ( IF 2.0 ) Pub Date : 2018-12-06 , DOI: 10.1007/s41981-018-0019-0 Judy Szeto , Vi-Anh Vu , Jeremiah P. Malerich , Nathan Collins
The development of a flow chemistry approach to the anti-fungal fluconazole is described. A continuous, two-reactor, three-step synthesis of fluconazole from 2-chloro-2′,4′-difluoroacetophenone was achieved with no intermediate purification. The synthesis has been successfully demonstrated on a Vapourtec commercial flow chemistry system.
中文翻译:
氟康唑的多步连续流合成
描述了抗真菌氟康唑的流化学方法的发展。从2-氯-2',4'-二氟苯乙酮连续,两反应器,三步合成氟康唑,无需中间纯化。该合成已在Vapourtec商业流化学系统上成功证明。