Abstract
The development of a flow chemistry approach to the anti-fungal fluconazole is described. A continuous, two-reactor, three-step synthesis of fluconazole from 2-chloro-2′,4′-difluoroacetophenone was achieved with no intermediate purification. The synthesis has been successfully demonstrated on a Vapourtec commercial flow chemistry system.
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Acknowledgements
This research was developed with funding from the Defense Advanced Research Projects Agency (DARPA, W911NF-16-C-0051). The views, opinions, and/or findings expressed are those of the author(s) and should not be interpreted as representing the official views or policies of the Department of Defense or the U.S. Government.
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Szeto, J., Vu, VA., Malerich, J.P. et al. Multi-step continuous flow synthesis of fluconazole. J Flow Chem 9, 35–42 (2019). https://doi.org/10.1007/s41981-018-0019-0
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DOI: https://doi.org/10.1007/s41981-018-0019-0