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Four hours of veno-venous extracorporeal membrane oxygenation using bi-caval cannulation affects kidney function and induces moderate lung damage in a mouse model
Intensive Care Medicine Experimental Pub Date : 2019-12-01 , DOI: 10.1186/s40635-019-0285-7
Ruslan Natanov 1 , Abdurasul Khalikov 1 , Faikah Gueler 2 , Ulrich Maus 3 , Erin C Boyle 1 , Axel Haverich 1 , Christian Kühn 1 , Nodir Madrahimov 1, 4
Affiliation  

BackgroundImprovement of single site cannulation for extracorporeal membrane oxygenation (ECMO) therapy is pivotal for reduction of patient morbidity and mortality in respiratory failure. To further improve the cardiopulmonary outcomes and reduce end organ damage, we established a murine model for single site cannulation with a double lumen cannula.ResultsWe created a hemodynamically stable double lumen cannula and successfully implanted it through the jugular vein into the upper and lower vena cava. This allowed adequate drainage of the blood. Blood gas analysis showed excellent oxygenation and CO2 reduction. There was no excessive bleeding. No signs of right heart congestion were present which was confirmed in the histological analysis of the liver. Histology demonstrated moderate lung damage and mild acute kidney injury. Neutrophil infiltration was similar in ECMO and sham kidneys.ConclusionsVeno-venous extracorporeal circulation deteriorates kidney function and promotes moderate pulmonary damage.

中文翻译:

使用双腔静脉插管进行四小时的静脉-静脉体外膜氧合影响肾功能并在小鼠模型中诱导中度肺损伤

背景体外膜肺氧合 (ECMO) 治疗的单点插管的改进对于降低呼吸衰竭患者的发病率和死亡率至关重要。为了进一步改善心肺结局并减少终末器官损伤,我们建立了双腔插管单点插管的小鼠模型。结果我们创建了一个血流动力学稳定的双腔插管,并成功地通过颈静脉将其植入上下腔静脉. 这允许充分排出血液。血气分析显示出极好的氧合和二氧化碳减少。没有过多出血。没有出现右心充血的迹象,这在肝脏的组织学分析中得到证实。组织学显示中度肺损伤和轻度急性肾损伤。
更新日期:2019-12-01
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