In the last decade, several reports highlight the importance of the low molecular weight protein tyrosine phosphatase (LMWPTP) in cancer aggressiveness and resistance. Specifically, in chronic myeloid leukemia, we have reported that high expression of the LMWPTP maintains Src and Bcr-Abl kinases in an activated status and the glucose metabolism is directed to lactate production and, in turn, favor the pentoses pathway (one of the key process for antioxidant and protective responses). In this present study, we investigated the possible correlation between the LMWPTP and autophagy. In resistant chronic myeloid leukemia cells, the antioxidant response is supported by the glycolytic metabolism and antioxidant enzymes such as SOD and catalase, both favored by the LMWPTP. Therefore, when the cells were challenged by hydrogen peroxide treatment, the LMWPTP level goes down as well as SOD, and in turn, autophagy process was stimulated. The findings presented here reveal a novel aspect by which LMWPTP cooperates for the resistance of CML towards stressor stimuli.

中文翻译：

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LMWPTP 调节人类慢性髓细胞白血病细胞的抗氧化反应和自噬过程。

在过去十年中，一些报告强调了低分子量蛋白酪氨酸磷酸酶 (LMWPTP) 在癌症侵袭性和抗性中的重要性。具体来说，在慢性粒细胞白血病中，我们报道了 LMWPTP 的高表达使 Src 和 Bcr-Abl 激酶保持在激活状态，并且葡萄糖代谢直接产生乳酸，进而有利于戊糖途径（关键之一抗氧化和保护反应的过程）。在本研究中，我们研究了 LMWPTP 与自噬之间可能的相关性。在耐药性慢性髓细胞白血病细胞中，抗​​氧化反应受到糖酵解代谢和抗氧化酶（如 SOD 和过氧化氢酶）的支持，这两者都受到 LMWPTP 的青睐。因此，当细胞受到过氧化氢处理的挑战时，LMWPTP 水平和 SOD 一样下降，进而刺激自噬过程。这里提出的研究结果揭示了一个新的方面，LMWPTP 通过该方面合作以抵抗 CML 对压力源刺激的抵抗。