In this study, we isolated two new neoflavones from Aconitum austroyunnanense and examined their therapeutic activity against osteoarthritis of the knee. All the tested compounds displayed good anti-inflammatory activity and significantly therapeutic activity against osteoarthritis of rats using surgically induced rat OA models. Compound 1 has the best therapeutic activity and appears to be a promising candidate for further development.

中文翻译：

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云南乌头的两种新黄酮及其对膝骨关节炎的治疗作用

在这项研究中，我们从云南乌头中分离了两种新黄酮，并检查了它们对膝关节骨关节炎的治疗活性。使用手术诱导的大鼠 OA 模型，所有测试的化合物都显示出良好的抗炎活性和显着的对大鼠骨关节炎的治疗活性。化合物 1 具有最好的治疗活性，似乎是进一步开发的有希望的候选者。