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Two Neoflavones from Aconitum Austroyunnanense and their Therapeutic Activity Against Osteoarthritis of the Knee

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Chemistry of Natural Compounds Aims and scope

In this study, we isolated two new neoflavones from Aconitum austroyunnanense and examined their therapeutic activity against osteoarthritis of the knee. All the tested compounds displayed good anti-inflammatory activity and significantly therapeutic activity against osteoarthritis of rats using surgically induced rat OA models. Compound 1 has the best therapeutic activity and appears to be a promising candidate for further development.

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Acknowledgment

This work was financially supported by the National Natural Science Foundation of China (81774341) and the Foundation of the Jiangsu Provincial Second Chinese Medicine Hospital (SEZJJZ201604).

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Authors and Affiliations

  1. Nanjing University of Chinese Medicine, 210023, Nanjing, P. R. China

    Ziqing Xu, Guicheng Huang & Yang Guo

  2. Jiangsu Provincial Second Chinese Medicine Hospital, 210017, Nanjing, P. R. China

    Ziqing Xu, Hongwei Ding & Baohua Zhu

  3. The Second Affiliated Hospital of Nanjing University of Chinese Medicine, 210017, Nanjing, P. R. China

    Ziqing Xu, Hongwei Ding & Baohua Zhu

  4. Traditional Chinese Medicine Hospital of Kunshan, 215300, Kunshan, P. R. China

    Shicheng Wu

Authors
  1. Ziqing Xu
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  2. Shicheng Wu
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  3. Guicheng Huang
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  4. Hongwei Ding
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  5. Baohua Zhu
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  6. Yang Guo
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Corresponding author

Correspondence to Guicheng Huang.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 1, January–February, 2020, pp. 59–62.

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Xu, Z., Wu, S., Huang, G. et al. Two Neoflavones from Aconitum Austroyunnanense and their Therapeutic Activity Against Osteoarthritis of the Knee. Chem Nat Compd 56, 62–66 (2020). https://doi.org/10.1007/s10600-020-02944-0

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  • DOI: https://doi.org/10.1007/s10600-020-02944-0

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