In this work, it is shown the development and validation of innovative analytical methodology based on solid-phase extraction (SPE) with molecularly imprinted polymers (MIP) as a sorbent associated to UV-Vis spectroscopy to isolate and quantify, respectively, rosuvastatin (RSV) in water samples. For this purpose, porogenic solvent in MIP synthesis and SPE extraction parameters for MIP and non-imprinted polymers (NIP) were evaluated univariately for comparison purposes. The sorptive capacity and characterization studies by infrared spectroscopy and atomic force microscopy showed difference between MIP and NIP. The selectivity study of the MIP-RSV against other statins (simvastatin and atorvastatin) showed that the synthesized MIP can also be applied as a solid phase for isolation and quantitative pre-concentration of RSV and atorvastatin. The conjugation of SPE and UV-Vis spectroscopy in the determination of RSV in aqueous matrices led to large factor of pre-concentration (125 times), limit of detection (LOD) of 3 μg L-1, limit of quantification (LOQ) of 10 μg L-1, precision of 2.87% (n = 10), and accuracy of 83.1% (n = 4).

中文翻译：

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在分子印迹聚合物中使用固相萃取对罗苏伐他汀进行预浓缩，并将其应用于供水中。

在这项工作中，显示了基于固相萃取（SPE）的创新分析方法的开发和验证，其中分子印迹聚合物（MIP）作为与UV-Vis光谱法相关的吸附剂，分别分离和定量了瑞舒伐他汀（RSV） ）在水样中。为此，对MIP和非印迹聚合物（NIP）的MIP合成中的成孔溶剂和SPE提取参数进行了单变量评估，以进行比较。通过红外光谱和原子力显微镜的吸附能力和表征研究表明，MIP和NIP之间存在差异。MIP-RSV对其他他汀类药物（辛伐他汀和阿托伐他汀）的选择性研究表明，合成的MIP还可以作为固相用于RSV和阿托伐他汀的分离和定量预浓缩。