Abstract
In this work, it is shown the development and validation of innovative analytical methodology based on solid-phase extraction (SPE) with molecularly imprinted polymers (MIP) as a sorbent associated to UV–Vis spectroscopy to isolate and quantify, respectively, rosuvastatin (RSV) in water samples. For this purpose, porogenic solvent in MIP synthesis and SPE extraction parameters for MIP and non-imprinted polymers (NIP) were evaluated univariately for comparison purposes. The sorptive capacity and characterization studies by infrared spectroscopy and atomic force microscopy showed difference between MIP and NIP. The selectivity study of the MIP–RSV against other statins (simvastatin and atorvastatin) showed that the synthesized MIP can also be applied as a solid phase for isolation and quantitative pre-concentration of RSV and atorvastatin. The conjugation of SPE and UV–Vis spectroscopy in the determination of RSV in aqueous matrices led to large factor of pre-concentration (125 times), limit of detection (LOD) of 3 μg L−1, limit of quantification (LOQ) of 10 μg L−1, precision of 2.87% (n = 10), and accuracy of 83.1% (n = 4).
Similar content being viewed by others
References
Andrade-Eiroa A, Canle M, Leroy-Cancellieri V, Cerda V (2016) Solid-phase extraction of organic compounds: a critical review (Part I). TrAC - Trends Anal Chem 80:641–654. https://doi.org/10.1016/j.trac.2015.08.015
Brown T (2015) The 10 most-prescribed and top-selling medications. In: WebMD. https://www.webmd.com/drug-medication/news/20150508/most-prescribed-top-selling-drug.
Bui BTS, Haupt K (2010) Molecularly imprinted polymers: synthetic receptors in bioanalysis. Anal Bioanal Chem 398:2481–2492. https://doi.org/10.1007/s00216-010-4158-x
Caldas SS, Gonçalves FF, Primel EG et al (2011) Modern techniques of sample preparation for pesticide residues determination in water by liquid chromatography with detection by diode array and mass spectrometry. Quim Nova 34:1604–1617. https://doi.org/10.1590/S0100-40422011000900021 (in Portuguese)
Campo VL, Carvalho I (2007) Hypolipemic statins and new therapeutcal trends. Quim Nova 30:425–430. https://doi.org/10.1590/S0100-40422007000200033 (in Portuguese)
Celermajer DS, Chow CK, Marijon E, Anstey NM, Woo KS (2012) Cardiovascular disease in the developing world: prevalences, patterns, and the potential of early disease detection. J Am Coll Cardiol 60:1207–1216. https://doi.org/10.1016/j.jacc.2012.03.074
Cheong WJ, Yang SH, Ali F (2013) Molecular imprinted polymers for separation science: a review of reviews. J Sep Sci 36:609–628. https://doi.org/10.1002/jssc.201200784
Devido R, Estatina D, Santos S, et al (2005) High doses statins administration causing rhabdomyolysis: case report. Arq Bras Endocrinol Metab 49:604–609. doi: https://doi.org/10.1590/S0004-27302005000400021 (in Portuguese)
Esther M, Padrón T, Afonso-olivares C et al (2014) Microextraction techniques coupled to liquid chromatography with mass spectrometry for the determination of organic micropollutants in environmental water samples. Molecules 19:10320–10349. https://doi.org/10.3390/molecules190710320
Ferreira SRC, Rocha AM, Saraiva JFK (2005) Statins in chronic renal disease. Arq Bras Cardiol 85:45–49. doi: https://doi.org/10.1590/S0066-782X2005002400012 (in Portuguese)
Figueiredo EC, Dias ACB, Arruda MAZ (2008) Molecular imprinting: a promising strategy in matrices elaboration for drug delivery systems. Brazilian J Pharm Sci 44:361–375. https://doi.org/10.1590/S1516-93322008000300005 (in Portuguese)
Fong C (2016) Statins in therapy: cellular transport, side effects, drug-drug interactions and cytotoxicity -the unrecognized role of lactones. [Research Report] Eigenenergy, Adelaide, Australia. 2016
Franqui LS, Vieira AC, Maia PP, Figueiredo EC (2012) Molecularly imprinted solid-phase extraction of urinary trans-trans muconic acid and analysis by gas chromatography-mass spectrometry. Quim Nova 35:1577–1581. doi: https://doi.org/10.1590/S0100-40422012000800016 (in Portuguese)
Furberg CD, Pitt B (2001) Withdrawal of cerivastatin from the world market. Curr Control Trials Cardiovasc Med 2:205–207. https://doi.org/10.1186/CVM-2-5-205
Gagliardi RJ, Sanches M, Rasslan Z, Guedes ML (1995) Comparative study of HDL and LDL cholesterol as risk factors for carotid atherosclerosis. Arq Neuropsiquiatr 53:730–736. doi: https://doi.org/10.1590/S0004-282X1995000500003 (in Portuguese)
Jardim ICSF (2010) Solid phase extraction: theoretical foundations and new strategies for solid phase preparation. Sci Chromatogr 2:13–25. Available from: <http://www.iicweb.org/scientiachromatographica.com/files/v2n1a2.pdf>. ISSN 1984-4433 (in Portuguese)
Krupadam RJ, Khan MS, Wate SR (2010) Removal of probable human carcinogenic polycyclic aromatic hydrocarbons from contaminated water using molecularly imprinted polymer. Water Res 44:681–688. https://doi.org/10.1016/j.watres.2009.09.044
Le Noir M, Lepeuple AS, Guieysse B, Mattiasson B (2007) Selective removal of 17β-estradiol at trace concentration using a molecularly imprinted polymer. Water Res 41:2825–2831. https://doi.org/10.1016/j.watres.2007.03.023
Lee HB, Peart TE, Lewina Svoboda M, Backus S (2009) Occurrence and fate of rosuvastatin, rosuvastatin lactone, and atorvastatin in Canadian sewage and surface water samples. Chemosphere 77:1285–1291. https://doi.org/10.1016/j.chemosphere.2009.09.068
Luo F, Huang S, Xiong X, Lai X (2015) Synthesis and characterization of Hg(II)-ion-imprinted polymer and its application for the determination of mercury in water samples. RSC Adv 5:67365–67371. https://doi.org/10.1039/c5ra10861f
Martín J, Buchberger W, Alonso E, Himmelsbach M, Aparicio I (2011) Comparison of different extraction methods for the determination of statin drugs in wastewater and river water by HPLC / Q-TOF-MS. Talanta 85:607–615. https://doi.org/10.1016/j.talanta.2011.04.017
Meng Z, Chen W, Mulchandani A (2005) Removal of estrogenic pollutants from contaminated water using molecularly imprinted polymers. Environ Sci Technol 39:8958–8962. https://doi.org/10.1021/es0505292
Murray A, Örmeci B (2012) Application of molecularly imprinted and non-imprinted polymers for removal of emerging contaminants in water and wastewater treatment: a review. Environ Sci Pollut Res 19:3820–3830. https://doi.org/10.1007/s11356-012-1119-2
Nerín C, Salafranca J, Aznar M, Batlle R (2009) Critical review on recent developments in solventless techniques for extraction of analytes. Anal Bioanal Chem 393:809–833. https://doi.org/10.1007/s00216-008-2437-6
Ottmar KJ, Colosi LM, Smith JA (2012) Fate and transport of atorvastatin and simvastatin drugs during conventional wastewater treatment. Chemosphere 88:1184–1189. https://doi.org/10.1016/j.chemosphere.2012.03.066
Pereira AMPT, Silva LJG, Meisel LM, Lino CM, Pena A (2015) Environmental impact of pharmaceuticals from Portuguese wastewaters: geographical and seasonal occurrence, removal and risk assessment. Environ Res 136:108–119. https://doi.org/10.1016/j.envres.2014.09.041
Philippidis A (2017) The top 15 best-selling drugs of 2016. In: Genet. Eng. e Biotechnol. News. https://www.genengnews.com/the-lists/the-top-15-best-selling-drugs-of-2016/77900868.
Pichon V, Chapuis-Hugon F (2008) Role of molecularly imprinted polymers for selective determination of environmental pollutants-a review. Anal Chim Acta 622:48–61. https://doi.org/10.1016/j.aca.2008.05.057
Quesada JAA (2017) Update in pharmacotherapy the pharmacology of statins: first part. Rev Costarric Cardiol 4:1–10. Available from: <http://www.scielo.sa.cr/scielo.php?script=sci_arttext&pid=S1409-41422002000100004&lng=en&nrm=iso>. ISSN 1409-4142. (in Spanish)
Samarth NB, Kamble V, Mahanwar PA et al (2015) A historical perspective and the development of molecular imprinting polymer-a review. Chem Int 4:202–210 Available from: http://bosaljournals.com/chemint/images/pdffiles/20.pdf
Santos Filho RD, Martinez TLDR (2002) Risk factors for cardiovascular disease: old and new risk factors, old problems! Arq Bras Endocrinol Metabol 46:212–214. doi: https://doi.org/10.1590/S0004-27302002000300002 (in Portuguese)
Shrivastava A, Gupta V (2011) Methods for the determination of limit of detection and limit of quantitation of the analytical methods. Chronicles Young Sci 2:21. https://doi.org/10.4103/2229-5186.79345
Sulaiman S, Khamis M, Nir S et al (2015) Stability and removal of atorvastatin, rosuvastatin and simvastatin from wastewater. Environ Technol 36:3232–3242. https://doi.org/10.1080/09593330.2015.1058422
Tabassum A, Arayne MS, Sultana N (2017) Synthesis and spectroscopic characterization of metal complexes of rosuvastatin. Indian J Pharm Educ Res 51:102–109. https://doi.org/10.5530/ijper.51.1.14
The European Agency for the Evaluation of Medicinal Products (1996) ICH topic Q2B note for guideline on validation of analytical procedures: Methodology GPMP/ICH/281/95. https://www.ema.europa.eu/en/documents/scientific-guideline/ich-q-2-r1-validation-analytical-procedures-text-methodology-step-5_en.pdf.
Vasapollo G, Del Sole R, Mergola L et al (2011) Molecularly imprinted polymers: present and future prospective. Int J Mol Sci 12:5908–5945. https://doi.org/10.3390/ijms12095908
WHO (2017) World heart day 2017. In: World Heal. Organ. http://www.who.int/cardiovascular_diseases/world-heart-day-2017/en/.
Funding
This study is supported by the Centro Federal de Educação Tecnológica Celso Suckow da Fonseca (CEFET-RJ), Fundação de Amparo à Pesquisa do Estado de Rio de Janeiro (FAPERJ), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).
Author information
Authors and Affiliations
Corresponding author
Additional information
Responsible Editor: Philipp Gariguess
Publisher’s note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
da Silva, W.A., Feiteira, F.N., Francisco, J.E. et al. Pre-concentration of rosuvastatin using solid-phase extraction in a molecularly imprinted polymer and analytical application in water supply. Environ Sci Pollut Res 27, 11724–11735 (2020). https://doi.org/10.1007/s11356-020-07742-3
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11356-020-07742-3