New series of 2,4,6-triarylpyridines derivatives 5a–f and 6a–d were designed, synthesized and evaluated for their cytotoxic activity against breast cancer cell lines. Three-component reaction between acetophenones, ammonium acetate and 4-methyl or 2-methylpyridine in the presence of iodine in DMSO lead to title 2,4,6-triarylpyridines. This method allows the simple preparation of the desired products using readily available reagents under mild reaction conditions in good yields. Synthesized compounds were investigated for their cytotoxic activities against MDA-MB-231, MCF-7 and T-47D cell lines. Most of the synthesized compounds showed remarkable cytotoxicity, comparable to standard drug etoposide.

设计，合成和评估了新的2,4,6-三芳基吡啶衍生物系列5a-f和6a-d对乳腺癌细胞系的细胞毒活性。在碘中，在DMSO中，苯乙酮，乙酸铵与4-甲基或2-甲基吡啶之间的三组分反应产生标题2,4,6-三芳基吡啶。该方法允许在温和的反应条件下使用容易获得的试剂以良好的收率简单地制备所需产物。研究了合成的化合物对MDA-MB-231，MCF-7和T-47D细胞系的细胞毒活性。与标准药物依托泊苷相比，大多数合成化合物显示出显着的细胞毒性。