Abstract

A novel and robust ionic liquid-supported copper(II) catalyst has been developed and explored for the efficient synthesis of 5-substituted-1H-tetrazoles using microwave irradiation. The ionic liquid-supported catalyst facilitated the efficient isolation of tetrazole products with high purity by simple extraction with organic solvent. Recovered ionic liquid-supported copper(II) catalyst could be recycled for three times for the synthesis of tetrazole products with high purity. This synthetic protocol offers a very clean, convenient, and microwave-assisted environment-friendly method for the efficient synthesis of 5-substituted-1H-tetrazoles with high yield.

Graphic abstract

摘要

已经开发了一种新颖且坚固的离子液体负载的铜（II）催化剂，并探索了利用微波辐射有效合成5-取代-1 H-四唑的方法。离子液体负载的催化剂通过简单地用有机溶剂萃取，促进了高纯度四唑产物的有效分离。回收的离子液体负载的铜（II）催化剂可循环使用三遍，以合成高纯度的四唑产品。该合成规程提供了一种非常干净，方便且微波辅助的环境友好的方法，可以高效地高效合成5-取代的-1 H-四唑。

图形摘要