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A robust and recyclable ionic liquid-supported copper(II) catalyst for the synthesis of 5-substituted-1H-tetrazoles using microwave irradiation

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Abstract

A novel and robust ionic liquid-supported copper(II) catalyst has been developed and explored for the efficient synthesis of 5-substituted-1H-tetrazoles using microwave irradiation. The ionic liquid-supported catalyst facilitated the efficient isolation of tetrazole products with high purity by simple extraction with organic solvent. Recovered ionic liquid-supported copper(II) catalyst could be recycled for three times for the synthesis of tetrazole products with high purity. This synthetic protocol offers a very clean, convenient, and microwave-assisted environment-friendly method for the efficient synthesis of 5-substituted-1H-tetrazoles with high yield.

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Acknowledgements

The authors thank the chancellor and vice chancellor of VIT University for providing opportunity to carry out this study. Further the authors wish to thank the management of this university for providing seed money as research grant. Kaushik Chanda thanks CSIR-Govt of India for funding through Grant no 01(2913)/17/EMR-II.

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Authors and Affiliations

  1. Department of Chemistry, School of Advanced Science, Vellore Institute of Technology, Vellore, 632014, India

    R. D. Padmaja & Kaushik Chanda

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  1. R. D. Padmaja
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  2. Kaushik Chanda
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Correspondence to Kaushik Chanda.

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11164_2019_4035_MOESM1_ESM.docx

The Supporting Information is available free of charge on the Publications Web site along with 1H and 13C NMR spectra of compounds 5 and 7a-l. (DOCX 1562 kb)

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Padmaja, R.D., Chanda, K. A robust and recyclable ionic liquid-supported copper(II) catalyst for the synthesis of 5-substituted-1H-tetrazoles using microwave irradiation. Res Chem Intermed 46, 1307–1317 (2020). https://doi.org/10.1007/s11164-019-04035-4

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  • DOI: https://doi.org/10.1007/s11164-019-04035-4

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