Abstract

Two new Ag–AgCl/CaCO₃ composite materials, with different molar ratios Ag:CaCO₃, were obtained in a green seaweed (Ulva lactuca) extract by a two steps synthesis. The first step consists in a green, partial reduction of Ag(I) in order to obtain Ag–AgCl crystals, which are deposited in the second step on CaCO₃. The composites were characterized by XRD, SEM, EDX, UV–vis, and FTIR spectroscopy. The morphology of composite materials consists in aggregates of calcite nanoparticles, decorated with Ag–AgCl, and the aggregates shape depends on the Ag(I):Ca(II) initial molar ratio. The aggregates are also capped with phytochemicals from green seaweeds, mainly polysaccharides. The composites can be used as a model for the utilization of calcium carbonate as silver carrier in medical applications. The dermatological properties of composites were tested in vivo for healing of burns. An accelerated healing was noticed for the composite with higher silver content. The promising results obtained in vivo recommend the Ag–AgCl/CaCO₃ composites for topical applications.

中文翻译：

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碳酸钙作为银载体在绿藻提取物中的复合材料中的局部应用

摘要

通过两步合成，在绿藻（Ulva lactuca）提取物中获得了两种摩尔比不同的新的Ag-AgCl / CaCO ₃复合材料：Ag：CaCO ₃。第一步是对Ag（I）进行绿色部分还原，以获得Ag–AgCl晶体，然后将其沉积在CaCO _3上。。通过XRD，SEM，EDX，UV-vis和FTIR光谱对复合材料进行表征。复合材料的形态包括方解石纳米粒子的聚集体，并用Ag–AgCl装饰，聚集体的形状取决于Ag（I）：Ca（II）的初始摩尔比。聚集体还被来自绿色海藻的植物化学物质（主要是多糖）覆盖。该复合材料可以用作在医疗应用中利用碳酸钙作为银载体的模型。在体内测试了复合物的皮肤病学特性以治疗烧伤。观察到具有较高银含量的复合材料加速了愈合。体内获得的令人鼓舞的结果推荐将Ag-AgCl / CaCO ₃复合材料用于局部应用。