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Calcium carbonate as silver carrier in composite materials obtained in green seaweed extract with topical applications

  • Original Paper: Sol-gel and hybrid materials for biological and health (medical) applications
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Abstract

Two new Ag–AgCl/CaCO3 composite materials, with different molar ratios Ag:CaCO3, were obtained in a green seaweed (Ulva lactuca) extract by a two steps synthesis. The first step consists in a green, partial reduction of Ag(I) in order to obtain Ag–AgCl crystals, which are deposited in the second step on CaCO3. The composites were characterized by XRD, SEM, EDX, UV–vis, and FTIR spectroscopy. The morphology of composite materials consists in aggregates of calcite nanoparticles, decorated with Ag–AgCl, and the aggregates shape depends on the Ag(I):Ca(II) initial molar ratio. The aggregates are also capped with phytochemicals from green seaweeds, mainly polysaccharides. The composites can be used as a model for the utilization of calcium carbonate as silver carrier in medical applications. The dermatological properties of composites were tested in vivo for healing of burns. An accelerated healing was noticed for the composite with higher silver content. The promising results obtained in vivo recommend the Ag–AgCl/CaCO3 composites for topical applications.

Highlights

  • Ag–AgCl/CaCO3 composites obtained in seaweed extract were successfully tested for burns healing.

  • Healing effect and oxidative activity increase with silver content.

  • Capping polysaccharides improve the topical activity of composites.

  • Calcite powder obtained in seaweed extract can be used as a silver carrier in topical treatment.

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Acknowledgements

AD acknowledges financial support through the Project No. 10 from order no. 397/27.05.2019 of JINR–VBLHEP, Dubna, Russia.

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Authors and Affiliations

  1. Department of Inorganic Chemistry, Physical Chemistry and Electrochemistry, University Politehnica of Bucharest, Bucharest, Romania

    Cristian Matei & Daniela Berger

  2. Department of Chemistry and Chemical Engineering, Ovidius University of Constanta, Constanta, Romania

    Anca Dumbrava

  3. Faculty of Natural and Agricultural Sciences, Ovidius University of Constanta, Constanta, Romania

    Marius Daniel Radu

  4. Faculty of Medicine, Ovidius University of Constanta, Constanta, Romania

    Emma Gheorghe

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  1. Cristian Matei
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Correspondence to Anca Dumbrava.

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Matei, C., Berger, D., Dumbrava, A. et al. Calcium carbonate as silver carrier in composite materials obtained in green seaweed extract with topical applications. J Sol-Gel Sci Technol 93, 315–323 (2020). https://doi.org/10.1007/s10971-019-05145-6

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