Abstract

A multifunctional nanoplatform (pSiO₂–Au/HA) combining porous silica (pSiO₂) carriers and gold nanoparticles (Au NPs) was synthesized for chemophotothermal synergistic therapy. The pSiO₂ carrier has the diameter size of 70 nm and high specific surface area (510.8 m²·g⁻¹). Au NPs as photothermal agents and gatekeepers were linked to pSiO₂ carriers by Au–S bonds for redox-responsive drug release and photothermal effect. Hyaluronic acid (HA) molecules were conjugated by the amide bonds on the surface of porous silica (pSiO₂) to seal the drug-loaded pores and endow it pH-and enzyme-responsive property. The results demonstrated that pSiO₂–Au/HA carriers displayed good pH/redox/enzyme-responsive release behavior and photothermal effect, which may be a good promising targeted delivery systems for chemophotothermal therapy.

中文翻译：

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三响应多孔二氧化硅载体与金纳米粒子的化学光热联合疗法

摘要

合成了多孔二氧化硅（pSiO ₂）载体和金纳米颗粒（Au NPs）相结合的多功能纳米平台（pSiO ₂ -Au / HA），用于化学光热协同治疗。pSiO ₂载体具有70nm的直径尺寸和高的比表面积（510.8m ² ·g ^-1）。Au NPs作为光热剂和看门人通过Au-S键与pSiO ₂载体相连，以实现氧化还原反应性药物释放和光热效应。透明质酸（HA）分子通过多孔二氧化硅（pSiO ₂）表面上的酰胺键结合，以密封载药孔，并赋予其pH和酶响应特性。结果表明，pSiO ₂-Au / HA载体显示出良好的pH /氧化还原/酶响应释放行为和光热效应，这可能是化学光热疗法的良好有希望的靶向递送系统。