Abstract
A multifunctional nanoplatform (pSiO2–Au/HA) combining porous silica (pSiO2) carriers and gold nanoparticles (Au NPs) was synthesized for chemophotothermal synergistic therapy. The pSiO2 carrier has the diameter size of 70 nm and high specific surface area (510.8 m2·g−1). Au NPs as photothermal agents and gatekeepers were linked to pSiO2 carriers by Au–S bonds for redox-responsive drug release and photothermal effect. Hyaluronic acid (HA) molecules were conjugated by the amide bonds on the surface of porous silica (pSiO2) to seal the drug-loaded pores and endow it pH-and enzyme-responsive property. The results demonstrated that pSiO2–Au/HA carriers displayed good pH/redox/enzyme-responsive release behavior and photothermal effect, which may be a good promising targeted delivery systems for chemophotothermal therapy.
Highlights
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Porous silica (pSiO2) carriers were successfully prepared for drug release.
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Hyaluronic acid (HA) and gold nanoparticles (Au NPs) are used to seal the loaded drug.
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pSiO2-Au/HA carriers display pH/redox/enzyme-responsive release behavior.
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pSiO2-Au/HA carriers exhibit good aqueous and photostability.
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References
Mahmoudi M, Sant S, Wang B, Laurent S, Sen T (2011) Adv Drug Deliv Rev 63:24–46
Zhang Z, Wang J, Chen C (2013) Adv Mater 25:3869–3880
Zhang X, Wang Y, Zhao Y, Sun L (2017) Mater Sci Eng C 77:19–26
Jiang W, Mo F, Jin X, Chen L, Xu LJ, Guo L, Fu F (2017) Adv Mater Interfaces 4:1700425
He H, Zhu R, Sun W, Cai K, Chen Y, Yin L (2018) Nanoscale 10:2856–2865
Ranji-Burachaloo H, Reyhani A, Gurr PA, Dunstan DE, Qiao GG (2019) Nanoscale 11:5705–5716
Markeb AA, El-Maali NA, Sayed DM, Osama A, Abdel-Malek MAY, Zaki AH, Elwanis MEA, Driscoll JJ (2016) Int J Breast Cancer 2016:1–8
Croissant JG, Fatieiev Y, Almalik A, Khashab NM (2018) Adv Healthc Mater 7:1700831
Cao N, Zhao Y, Sang B, Wang Z, Cao L, Sun L, Zou X (2016) Mater Sci Eng C 69:330–336
Cao N, Xie X, Zhang Y, Zhao Y, Cao L, Sun L (2016) J Ind Eng Chem 34:9–13
Zhang Q, Guo J, Zhang X, Zhao Y, Cao L, Sun L (2018) Sens Actuators B 276:370–377
Montoto AH, Montes R, Samadi A, Gorbe M, Terrés JM, Cao-Milán R, Aznar E, Ibañez J, Masot R, Marcos MD, Orzáez M, Sancenón F, Oddershede LB, Martínez-Máñez R (2018) ACS Appl Mater Interfaces 10:27644–27656
Zhang Z, Wang J, Nie X, Wen T, Ji Y, Wu X, Zhao Y, Chen C (2014) J Am Chem Soc 136:7317–7326
Moreira AF, Rodrigues CF, Reis CA, Costa EC, Correia IJ (2018) Microporous Mesoporous Mater 270:168–179
Hu Y, Liu Y, Xie X, Bao W, Hao J (2018) J Colloid Interface Sci 529:547–555
Villaverde G, Gómez-Graña S, Guisasola E, García I, Hanske C, Liz-Marzán LM, Baeza A, Vallet-Regí M (2018) Part Part Syst Charact 35:1800148
Poudel BK, Soe ZC, Ruttala HB, Gupta B, Ramasamy T, Thapa RK, Gautam M, Ou W, Nguyen HT, Jeong J-H, Jin SG, Choi H-G, Yong CS, Kim JO (2018) Int J Pharm 548:92–103
Huang X, Tang S, Mu X, Dai Y, Chen G, Zhou Z, Ruan F, Yang Z, Zheng N (2010) Nat Nanotech 6:28–32
Yang Y, Lin Y, Di D, Zhang X, Wang D, Zhao Q, Wang S (2017) J Colloid Interface Sci 508:323–331
Mattheolabakis G, Milane L, Singh A, Amiji MM (2015) J Drug Target 23:605–618
Du X, Li X, Huang H, He J, Zhang X (2015) Nanoscale 7:6173–6184
Tournebize J, Boudier A, Sapin-Minet A, Maincent P, Leroy P, Schneider R (2012) ACS Appl Mater Interfaces 4:5790–5799
Qiu L, Zhao Y, Cao N, Cao L, Sun L, Zou X (2016) Sens Actuators B 234:21–26
Zhang X, Zhao Y, Cao L, Sun L (2018) Sens Actuators B 257:105–115
Zhou H, Xu H, Li X, Lv Y, Ma T, Guo S, Huang Z, Wang X, Xu P (2017) Mater Sci Eng C 81:261–270
Rahoui N, Jiang B, Hegazy M, Taloub N, Wang Y, Yu M, Huang YD (2018) Colloids Surf B 171:176–185
Guo Z, Zheng K, Tan Z, Liu Y, Zhao Z, Zhu G, Ma K, Cui C, Wang L, Kang T (2018) J Mater Chem B 6:7750–7759
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Financial support of this work from National Natural Science Foundation of China (21271062) is gratefully acknowledged.
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Chen, Y., Zhao, Y., Sun, L. et al. Tri-responsive porous silica carrier with gold nanoparticles for chemophotothermal combination therapy. J Sol-Gel Sci Technol 93, 332–340 (2020). https://doi.org/10.1007/s10971-019-05183-0
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DOI: https://doi.org/10.1007/s10971-019-05183-0