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Maternal effects as causes of risk for obsessive-compulsive disorder
Biological Psychiatry ( IF 11.501 ) Pub Date : 2020-01-22 , DOI: 10.1016/j.biopsych.2020.01.006
Behrang Mahjani; Lambertus Klei; Christina M. Hultman; Henrik Larsson; Bernie Devlin; Joseph D. Buxbaum; Sven Sandin; Dorothy E. Grice

Background While genetic variation has a known impact on the risk for obsessive‐compulsive disorder (OCD), there is also evidence that there are maternal components to this risk. Here, we partition sources of variation, namely direct genetic and maternal genetic effects, on risk for OCD. Methods The study population consists of 822,843 individuals from the Swedish Medical Birth Register, born in Sweden between January 1, 1982, to December 31, 1990, and followed for a diagnosis of OCD through December 31, 2013. Diagnostic information about OCD was obtained using the Swedish National Patient Register. Results 7,184 (0.87%) individuals in the birth cohort were diagnosed with OCD. After exploring various generalized linear mixed models to fit the diagnostic data, genetic maternal effects accounted for 7.6% (95% CI, 6.9%-8.3%) of the total variance in risk for OCD for the best model and direct additive genetics for 35% (95% CI, 32.3%-36.9%). These findings were robust under alternative models. Conclusions Our results establish genetic maternal effects as influencing risk for OCD in offspring. We also show that additive genetic effects in OCD are overestimated when maternal effects are not modeled.
更新日期:2020-01-22

 

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