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A link between metabolic energetics and pancreatic cancer mechanosensing.
Nature Metabolism ( IF 18.9 ) Pub Date : 2020-01-20 , DOI: 10.1038/s42255-019-0165-1
Maria V Liberti 1, 2 , Kivanc Birsoy 2
Affiliation  

Extracellular-matrix remodelling contributes to tumour progression, results in intratumoural fibrosis and promotes metastatic behaviour. A new study by Papalazarou et al. now reveals that a pathway involved in ATP supply, the creatine phosphagen system, is a mechanosensitive target during pancreatic cancer invasion.

中文翻译:

代谢能与胰腺癌机械传感之间的联系。

细胞外基质重塑有助于肿瘤进展,导致肿瘤内纤维化并促进转移行为。Papalazarou等人的一项新研究。现在揭示了参与ATP供应的一种途径,即肌酸磷酸酶系统,是胰腺癌侵袭期间的机械敏感靶标。
更新日期:2020-01-20
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