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A link between metabolic energetics and pancreatic cancer mechanosensing

Nature Metabolism volume 2, pages 5–6 (2020)Cite this article

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Extracellular-matrix remodelling contributes to tumour progression, results in intratumoural fibrosis and promotes metastatic behaviour. A new study by Papalazarou et al. now reveals that a pathway involved in ATP supply, the creatine phosphagen system, is a mechanosensitive target during pancreatic cancer invasion.

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Fig. 1: ECM remodelling is an important component of cancer metastasis that results in stromal stiffness and consequently in environmental stress.

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Authors and Affiliations

  1. Laboratory of Systems Cancer Biology, The Rockefeller University, New York, NY, USA

    Maria V. Liberti

  2. Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA

    Maria V. Liberti & Kivanc Birsoy

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  1. Maria V. Liberti
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  2. Kivanc Birsoy
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Correspondence to Kivanc Birsoy.

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The authors declare no competing interests.

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Liberti, M.V., Birsoy, K. A link between metabolic energetics and pancreatic cancer mechanosensing. Nat Metab 2, 5–6 (2020). https://doi.org/10.1038/s42255-019-0165-1

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