This study investigated the association between body composition and risk of atrial fibrillation (AF) in postmenopausal women. In a retrospective analysis we assessed data from 5704 postmenopausal women (age 70.7 ± 6.5 yrs.) who in 1999-2001 participated in The Prospective Epidemiological Risk Factor study with body composition assessed by dual-energy X-ray absorptiometry. Outcomes were obtained from Danish Health Registries and body composition association to risk of AF was evaluated by univariable and multivariable Cox Hazard regression. 850 women developed AF after baseline. High lean body mass was associated with increased risk of AF in multivariable analyses, adjusting for body mass index (BMI), height or weight (adjusted for: BMI, hazard ratio (HR) 1.49, 95% Confidence Interval (1.22-1.80); height, HR 1.27 (1.03-1.56); weight, 1.33 (1.06-1.65)). Height and weight were associated with increased risk of AF in multivariable analyses adjusting for body composition measures. When adjusting for total lean mass, only height remained statistically significant (HR 1.34 (1.09-1.64)). In a cohort of elderly Caucasian women, high lean body mass, height and weight were associated with increased risk of AF and the variables remained significant after adjusting for age and other known risk factors of AF.

中文翻译：

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绝经后妇女的房颤与瘦体重有关。

这项研究调查了绝经后妇女的身体成分与房颤（AF）风险之间的关系。在一项回顾性分析中，我们评估了5704名绝经后妇女（年龄70.7±6.5岁）的数据，这些妇女在1999-2001年参加了前瞻性流行病学危险因素研究，并通过双能X射线吸收法评估了其身体成分。从丹麦卫生注册局获得结果，并通过单变量和多变量Cox Hazard回归评估身体成分与房颤风险的关联性。850名女性在基线后出现房颤。高瘦体重在多变量分析中与房颤风险增加相关，对体重指数（BMI），身高或体重进行了调整（校正后：BMI，危险比（HR）1.49、95％置信区间（1.22-1.80）；身高，HR 1.27（1.03-1.56）；体重，1.33（1.06-1。65））。在针对身体成分进行调整的多变量分析中，身高和体重与房颤风险增加相关。当调整总瘦体重时，只有身高保持统计学上的显着性（HR 1.34（1.09-1.64））。在一群高加索白人妇女中，高瘦体重，身高和体重与AF风险增加有关，并且在校正年龄和其他已知的AF风险因素后，变量仍然很显着。