Tumour innervation and neurosignalling in prostate cancer.,Nature Reviews Urology

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Tumour innervation and neurosignalling in prostate cancer.
Nature Reviews Urology ( IF 12.1 ) Pub Date : 2020-01-14 , DOI: 10.1038/s41585-019-0274-3
Brayden March _{1,

2,

3} , Sam Faulkner _{3,

4} , Phillip Jobling _{3,

4} , Allison Steigler _{1,

5} , Alison Blatt ₂ , Jim Denham _{1,

5} , Hubert Hondermarck _{3,

4}

Affiliation

Prostate cancer progression has been shown to be dependent on the development of autonomic nerves into the tumour microenvironment. Sympathetic nerves activate adrenergic neurosignalling that is necessary in early stages of tumour progression and for initiating an angiogenic switch, whereas parasympathetic nerves activate cholinergic neurosignalling resulting in tumour dissemination and metastasis. The innervation of prostate cancer seems to be initiated by neurotrophic growth factors, such as the precursor to nerve growth factor secreted by tumour cells, and the contribution of brain-derived neural progenitor cells has also been reported. Current experimental, epidemiological and clinical evidence shows the stimulatory effect of tumour innervation and neurosignalling in prostate cancer. Using nerves and neurosignalling could have value in the management of prostate cancer by predicting aggressive disease, treating localized disease through denervation and relieving cancer-associated pain in bone metastases.

中文翻译：

前列腺癌中的肿瘤神经支配和神经信号传递。

前列腺癌的进展已显示取决于自主神经向肿瘤微环境的发展。交感神经激活在肿瘤进展早期和启动血管生成转换所必需的肾上腺素能神经信号传递，而副交感神经则激活导致肿瘤扩散和转移的胆碱能神经信号传递。前列腺癌的神经支配似乎是由神经营养性生长因子引起的，例如肿瘤细胞分泌的神经生长因子的前体，并且也有报道称脑源性神经祖细胞的贡献。当前的实验，流行病学和临床证据表明，肿瘤神经支配和神经信号传导对前列腺癌具有刺激作用。

更新日期：2020-01-14

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