Going through a phase.,Nature Chemical Biology

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Going through a phase.
Nature Chemical Biology ( IF 12.9 ) Pub Date : 2020-01-13 , DOI: 10.1038/s41589-019-0448-6
Zhipeng Li ₁ , Siti Nur Sarah Morris ₁ , James A Olzmann _{1,

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Affiliation

Genetic screens uncover a bioactivation pathway for Lasonolide A involving enrichment in lipid droplets and cleavage into a cytotoxic, soluble metabolite by a lipid droplet-associated serine hydrolase. These findings identify enzymatically regulated phase partitioning as a drug activation mechanism.

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