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LIPID BIOLOGY

Going through a phase

Nature Chemical Biology volume 16, pages 111–112 (2020)Cite this article

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Genetic screens uncover a bioactivation pathway for Lasonolide A involving enrichment in lipid droplets and cleavage into a cytotoxic, soluble metabolite by a lipid droplet-associated serine hydrolase. These findings identify enzymatically regulated phase partitioning as a drug activation mechanism.

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Fig. 1: Enzymatic processing by the ER and lipid droplet localized hydrolase LDAH controls LasA phase partitioning and cytotoxicity.

References

  1. Walther, T. C., Chung, J. & Farese, R. V. Jr. Annu. Rev. Cell Dev. Biol. 33, 491–510 (2017).

    Article  CAS  Google Scholar 

  2. Olzmann, J. A. & Carvalho, P. Nat. Rev. Mol. Cell Biol. 20, 137–155 (2019).

    Article  CAS  Google Scholar 

  3. Dubey, R. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-019-0447-7 (2020).

  4. Isbrucker, R. A., Guzmán, E. A., Pitts, T. P. & Wright, A. E. J. Pharmacol. Exp. Ther. 331, 733–739 (2009).

    Article  CAS  Google Scholar 

  5. Horton, P. A., Koehn, F. E., Longley, R. E. & McConnell, O. J. J. Am. Chem. Soc. 116, 6015–6016 (1994).

    Article  CAS  Google Scholar 

  6. Zhang, Y.-W., Ghosh, A. K. & Pommier, Y. Cell Cycle 11, 4424–4435 (2012).

    Article  CAS  Google Scholar 

  7. Goo, Y.-H., Son, S.-H., Kreienberg, P. B. & Paul, A. Arterioscler. Thromb. Vasc. Biol. 34, 386–396 (2014).

    Article  CAS  Google Scholar 

  8. Goo, Y.-H., Son, S.-H. & Paul, A. Sci. Rep. 7, 2743 (2017).

    Article  Google Scholar 

  9. Kory, N. et al. J. Lipid Res. 58, 226–235 (2017).

    Article  CAS  Google Scholar 

  10. Greenwood, D. J. et al. Science 364, 1279–1282 (2019).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA, USA

    Zhipeng Li, Siti Nur Sarah Morris & James A. Olzmann

  2. Chan Zuckerberg Biohub, San Francisco, CA, USA

    James A. Olzmann

Authors
  1. Zhipeng Li
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  2. Siti Nur Sarah Morris
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  3. James A. Olzmann
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Correspondence to James A. Olzmann.

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The authors declare no competing interests.

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Li, Z., Morris, S.N.S. & Olzmann, J.A. Going through a phase. Nat Chem Biol 16, 111–112 (2020). https://doi.org/10.1038/s41589-019-0448-6

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