High dietary glycaemic index (GI) and glycaemic load (GL) may increase cancer risk. However, limited information was available on GI and/or GL and head and neck cancer (HNC) risk. We conducted a pooled analysis on 8 case-control studies (4081 HNC cases; 7407 controls) from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. We estimated the odds ratios (ORs) and 95% confidence intervals (CIs) of HNC, and its subsites, from fixed- or mixed-effects logistic models including centre-specific quartiles of GI or GL. GI, but not GL, had a weak positive association with HNC (ORQ4 vs. Q1 = 1.16; 95% CI = 1.02-1.31). In subsites, we found a positive association between GI and laryngeal cancer (ORQ4 vs. Q1 = 1.60; 95% CI = 1.30-1.96) and an inverse association between GL and oropharyngeal cancer (ORQ4 vs. Q1 = 0.78; 95% CI = 0.63-0.97). This pooled analysis indicates a modest positive association between GI and HNC, mainly driven by laryngeal cancer.

中文翻译：

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膳食血糖指数、血糖负荷和头颈癌风险：国际财团的汇总分析。

高膳食血糖指数 (GI) 和血糖负荷 (GL) 可能会增加患癌症的风险。然而，关于 GI 和/或 GL 和头颈癌 (HNC) 风险的信息有限。我们对来自国际头颈癌流行病学 (INHANCE) 联盟的 8 项病例对照研究（4081 例 HNC 病例；7407 例对照）进行了汇总分析。我们从固定或混合效应逻辑模型（包括 GI 或 GL 的中心特定四分位数）估计了 HNC 及其子位点的优势比 (OR) 和 95% 置信区间 (CI)。GI（而非 GL）与 HNC 呈弱正相关（ORQ4 与 Q1 = 1.16；95% CI = 1.02-1.31）。在亚位点，我们发现 GI 与喉癌之间呈正相关（ORQ4 与 Q1 = 1.60；95% CI = 1.30-1.96），而 GL 与口咽癌之间呈负相关（ORQ4 与 Q1 = 0.78；95% CI = 0.63-0.97)。