Recent decades, there is significant progress in understanding the mechanisms of tumor progression and immune evasion. The newly discovered protein NLRC5 is demonstrated to participate in regulating cancer immune escape through enhancing MHC class I genes expression in certain tumors. Nevertheless, increasing evidence has revealed that NLRC5 is up-regulated in some other tumors and promote tumor development and progression. The purpose of this review is to describe the role of NLRC5 in tumors and discuss whether NLRC5 can be a potential target in cancer treatment.

中文翻译：

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NLRC5：新的癌症破坏者？

近几十年来，在了解肿瘤进展和免疫逃逸的机制方面取得了重大进展。事实证明，新发现的蛋白质NLRC5通过增强某些肿瘤中的MHC I类基因表达参与调节癌症的免疫逃逸。然而，越来越多的证据表明，NLRC5在其他一些肿瘤中被上调并促进肿瘤的发展和进展。这篇综述的目的是描述NLRC5在肿瘤中的作用，并讨论NLRC5是否可以成为癌症治疗的潜在靶标。