Objective

To examine the association between maternal erythrocyte long-chain omega-3 PUFA (n-3 LCPUFA), measured in early pregnancy, and pregnancy and birth outcomes.

Study Design

One hundred and eight healthy women with a singleton pregnancy were included. Erythrocyte fatty acids were analyzed using gas chromatography. Gestational length, birth anthropometric measures, and pregnancy-associated complications were collected from hospital medical records.

Results

We observed significant positive associations between maternal docosahexaenoic acid (DHA) levels (p = 0.024) and omega-3 index values (p = 0.021) and gestational length in adjusted linear regression models. Each point in maternal DHA level was associated with 2.19 days longer gestational duration (β = 2.19; 95% CI 0.29–4.09). No consistent associations were found between n-3 PUFA levels and composite pregnancy outcome.

Conclusion

These findings suggest that the gestational length is positively affected by maternal n-3 LCPUFA status as soon as the early stages of pregnancy.

中文翻译：

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妊娠早期红细胞长链 omega-3 多不饱和脂肪酸水平对出生结局的影响：比利时队列研究的结果

客观的

研究在妊娠早期测量的母体红细胞长链 omega-3 PUFA (n-3 LCPUFA) 与妊娠和分娩结果之间的关联。

学习规划

包括 108 名单胎妊娠的健康女性。使用气相色谱分析红细胞脂肪酸。从医院病历中收集妊娠长度、出生人体测量指标和妊娠相关并发症。

结果

 我们在调整后的线性回归模型中观察到母体二十二碳六烯酸 (DHA) 水平 ( p  = 0.024) 和 omega-3 指数值 ( p = 0.021) 与妊娠长度之间存在显着的正相关。母体 DHA 水平的每个点都与孕期延长 2.19 天相关（β  = 2.19；95% CI 0.29–4.09）。在 n-3 PUFA 水平和复合妊娠结局之间没有发现一致的关联。

结论

这些研究结果表明，一旦怀孕早期，孕期长度就会受到母体 n-3 LCPUFA 状态的积极影响。