Journal of Perinatology ( IF 2.4 ) Pub Date : 2020-01-08 , DOI: 10.1038/s41372-019-0573-9 Axelle Hoge 1 , Anne-Françoise Donneau 1 , Nadia Dardenne 1 , Sylvie Degée 2 , Marie Timmermans 2 , Michelle Nisolle 2 , Michèle Guillaume 1 , Vincenzo Castronovo 3
Objective
To examine the association between maternal erythrocyte long-chain omega-3 PUFA (n-3 LCPUFA), measured in early pregnancy, and pregnancy and birth outcomes.
Study Design
One hundred and eight healthy women with a singleton pregnancy were included. Erythrocyte fatty acids were analyzed using gas chromatography. Gestational length, birth anthropometric measures, and pregnancy-associated complications were collected from hospital medical records.
Results
We observed significant positive associations between maternal docosahexaenoic acid (DHA) levels (p = 0.024) and omega-3 index values (p = 0.021) and gestational length in adjusted linear regression models. Each point in maternal DHA level was associated with 2.19 days longer gestational duration (β = 2.19; 95% CI 0.29–4.09). No consistent associations were found between n-3 PUFA levels and composite pregnancy outcome.
Conclusion
These findings suggest that the gestational length is positively affected by maternal n-3 LCPUFA status as soon as the early stages of pregnancy.
中文翻译:
妊娠早期红细胞长链 omega-3 多不饱和脂肪酸水平对出生结局的影响:比利时队列研究的结果
客观的
研究在妊娠早期测量的母体红细胞长链 omega-3 PUFA (n-3 LCPUFA) 与妊娠和分娩结果之间的关联。
学习规划
包括 108 名单胎妊娠的健康女性。使用气相色谱分析红细胞脂肪酸。从医院病历中收集妊娠长度、出生人体测量指标和妊娠相关并发症。
结果
我们在调整后的线性回归模型中观察到母体二十二碳六烯酸 (DHA) 水平 ( p = 0.024) 和 omega-3 指数值 ( p = 0.021) 与妊娠长度之间存在显着的正相关。母体 DHA 水平的每个点都与孕期延长 2.19 天相关(β = 2.19;95% CI 0.29–4.09)。在 n-3 PUFA 水平和复合妊娠结局之间没有发现一致的关联。
结论
这些研究结果表明,一旦怀孕早期,孕期长度就会受到母体 n-3 LCPUFA 状态的积极影响。