Pancreatic cancer (PC) remains one of the most extremely lethal malignancies worldwide due to late diagnosis and early metastasis, with a 1-year overall survival rate of approximately 20%. The hypoxic microenvironment, induced by intratumoral hypoxia, promotes tumor invasion and progression, leading to chemotherapy or radiotherapy resistance and eventual mortality after treatment of PC. However, the role of the hypoxic microenvironment in PC is complicated and requires further investigation. In this article, we review recent advances regarding the regulation of malignant behaviors in PC, which provide insight into the potential of hypoxic microenvironment activation therapy for the therapeutic agents.

中文翻译：

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缺氧：征服胰腺癌的路障。


由于诊断较晚、转移较早，胰腺癌（PC）仍然是全球最致命的恶性肿瘤之一，其 1 年总生存率约为 20%。瘤内缺氧引起的缺氧微环境促进肿瘤侵袭和进展，导致化疗或放疗耐药，并最终导致PC治疗后死亡。然而，缺氧微环境在PC中的作用很复杂，需要进一步研究。在本文中，我们回顾了有关 PC 恶性行为调节的最新进展，这些进展为治疗药物的低氧微环境激活疗法的潜力提供了见解。