Familial Mediterranean fever is a chronic inflammatory disease characterized by periodic and self-limited episodes of fever and aseptic polyserositis. Although colchicine treatment has altered the course of the disease, it is believed that subclinical inflammation is still present, leading to endothelial dysfunction and atherosclerosis in the course of time. In this review, following the published recommendations, we queried online databases such as MEDLINE Pubmed, Scopus, and Web of science for peer-reviewed studies and reviews written in English language, using the following keywords: familial Mediterranean fever, children, endothelial dysfunction, atherosclerosis, cardiovascular disease. The objective of this review is to highlight the correlation between familial Mediterranean fever and atherosclerosis, and moreover to describe new serum inflammatory markers and non-invasive methods of endothelial dysfunction, to detect the atherosclerosis process early starting from childhood.

中文翻译：

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儿童和青少年的家族性地中海热和动脉粥样硬化

家族性地中海热是一种慢性发炎性疾病，其特征是发烧和无菌性多发性浆膜炎的周期性和自限性发作。尽管秋水仙碱的治疗改变了疾病的进程，但据信亚临床炎症仍然存在，随着时间的推移导致内皮功能障碍和动脉粥样硬化。在此评论中，根据已发布的建议，我们查询了MEDLINE Pubmed，Scopus和Web of Science等在线数据库，以英语进行同行评审研究和评论，并使用以下关键字：家族性地中海热，儿童，内皮功能障碍，动脉粥样硬化，心血管疾病。这篇评论的目的是强调家族性地中海热与动脉粥样硬化之间的相关性，