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Familial Mediterranean fever and atherosclerosis in childhood and adolescence

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Abstract

Familial Mediterranean fever is a chronic inflammatory disease characterized by periodic and self-limited episodes of fever and aseptic polyserositis. Although colchicine treatment has altered the course of the disease, it is believed that subclinical inflammation is still present, leading to endothelial dysfunction and atherosclerosis in the course of time. In this review, following the published recommendations, we queried online databases such as MEDLINE Pubmed, Scopus, and Web of science for peer-reviewed studies and reviews written in English language, using the following keywords: familial Mediterranean fever, children, endothelial dysfunction, atherosclerosis, cardiovascular disease. The objective of this review is to highlight the correlation between familial Mediterranean fever and atherosclerosis, and moreover to describe new serum inflammatory markers and non-invasive methods of endothelial dysfunction, to detect the atherosclerosis process early starting from childhood.

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Abbreviations

AA:

Amyloid A

ADDI:

Autoinflammatory disease damage index

ADMA:

Asymmetric dimethylarginine

AI:

Augmentation index

CRP:

C-reactive protein

CVD:

Cardiovascular disease

EF:

Ejection fraction

ESR:

Erythrocyte sedimentation rate

FMD:

Flow-mediated dilation

FMF:

Familial Mediterranean fever

HDL-C:

High-density lipoprotein

IL-1β:

Interleukin 1-β

IMT:

Intima–media thickness

MEFV:

Mediterranean fever

MPV:

Mean platelet volume

NLR:

NOD-like receptor

NLR:

Neutrophil–leukocyte ratio

NLRP3:

NOD-like receptor family, pyrindomain

PAI-1:

Plasminogen-1 activator inhibitor

PLR:

Platelet–leukocyte ratio

PWA:

Pulse wave analysis

PWV:

Pulse wave velocity

RDW:

Red cell distribution width

SAA:

Serum amyloid A

TDI:

Tissue Doppler Imaging

TG:

Triglyceride levels

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Authors and Affiliations

  1. 4th Department of Pediatrics, “Papageorgiou” Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece

    Olga Vampertzi, Kyriaki Papadopoulou-Legbelou & Efimia Papadopoulou-Alataki

  2. 3rd Department of Internal Medicine, “Papageorgiou” Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece

    Areti Triantafyllou & Stella Douma

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  1. Olga Vampertzi
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  2. Kyriaki Papadopoulou-Legbelou
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Vampertzi, O., Papadopoulou-Legbelou, K., Triantafyllou, A. et al. Familial Mediterranean fever and atherosclerosis in childhood and adolescence. Rheumatol Int 40, 1–8 (2020). https://doi.org/10.1007/s00296-019-04457-8

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