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XRCC1 Arg194Trp polymorphism and thyroid cancer.
Journal of Endocrinological Investigation ( IF 5.4 ) Pub Date : 2019-12-09 , DOI: 10.1007/s40618-019-01155-x S-Y Liu 1 , W Xue 1
Journal of Endocrinological Investigation ( IF 5.4 ) Pub Date : 2019-12-09 , DOI: 10.1007/s40618-019-01155-x S-Y Liu 1 , W Xue 1
Affiliation
BACKGROUND
Previously published data on the association between the XRCC1 Arg194Trp polymorphism and thyroid cancer (TC) remain controversial.
METHODS
To clarify the association between the XRCC1 Arg194Trp polymorphism and susceptibility to TC, a meta-analysis of case-control studies was conducted. We systematically searched PubMed and CNKI to identify relevant studies. Pooled odds ratios (ORs) of various genetic models were estimated using fixed and random effects models. Heterogeneity was detected by Q-statistic, and the Egger's test was used to evaluate the publication bias.
RESULTS
A total of seven eligible studies for the XRCC1 Arg194Trp polymorphism (1500 patients and 2358 controls) were included in this meta-analysis. The results of our study failed to suggest an association between the Arg194Trp polymorphism and susceptibility of TC. However, in the subgroup analyses by ethnicity, the OR was 0.82 (C allele vs. T allele, 95% CI 0.68-0.98; P = 0.24 for heterogeneity) among the Chinese population. Nevertheless, no significant differences were observed in the Caucasian population in any genetic model.
CONCLUSION
This study suggested that the C allele of XRCC1 had an 18% significantly decreased risk of TC in Chinese, and there were no significant associations among Caucasians under all genetic models.
更新日期：2019-12-09
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