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XRCC1 Arg194Trp polymorphism and thyroid cancer

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Abstract

Background

Previously published data on the association between the XRCC1 Arg194Trp polymorphism and thyroid cancer (TC) remain controversial.

Methods

To clarify the association between the XRCC1 Arg194Trp polymorphism and susceptibility to TC, a meta-analysis of case–control studies was conducted. We systematically searched PubMed and CNKI to identify relevant studies. Pooled odds ratios (ORs) of various genetic models were estimated using fixed and random effects models. Heterogeneity was detected by Q-statistic, and the Egger’s test was used to evaluate the publication bias.

Results

A total of seven eligible studies for the XRCC1 Arg194Trp polymorphism (1500 patients and 2358 controls) were included in this meta-analysis. The results of our study failed to suggest an association between the Arg194Trp polymorphism and susceptibility of TC. However, in the subgroup analyses by ethnicity, the OR was 0.82 (C allele vs. T allele, 95% CI 0.68–0.98; P = 0.24 for heterogeneity) among the Chinese population. Nevertheless, no significant differences were observed in the Caucasian population in any genetic model.

Conclusion

This study suggested that the C allele of XRCC1 had an 18% significantly decreased risk of TC in Chinese, and there were no significant associations among Caucasians under all genetic models.

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Authors and Affiliations

  1. Department of Pediatric and Thyroid Surgery, The Third Affiliated Hospital of Soochou University, 185 Juqian Street, Changzhou, 213000, People’s Republic of China

    S.-Y. Liu & W. Xue

Authors
  1. S.-Y. Liu
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  2. W. Xue
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Contributions

All authors participated in the study. LSY and XW performed the literature search and the extraction of data. LSY performed the data analysis. LSY and XW participated in the interpretation of data and the writing of the manuscript. XW revised the article for important intellectual content. All authors read and approved the final manuscript.

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Correspondence to W. Xue.

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Liu, SY., Xue, W. XRCC1 Arg194Trp polymorphism and thyroid cancer. J Endocrinol Invest 43, 749–753 (2020). https://doi.org/10.1007/s40618-019-01155-x

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  • DOI: https://doi.org/10.1007/s40618-019-01155-x

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