OBJECTIVES Demineralizations such as white spot lesions are among the most prevalent side effects during orthodontic treatment. Fluorescence devices, including quantitative light-induced fluorescence (QLF), exploiting the intrinsic fluorescence of enamel and teeth and most recently optical coherence tomography (OCT) were introduced for early demineralization detection. In addition to near-infrared OCT scanning, multicolor modules allow for imaging with different laser wavelengths and the detection of reflective- and fluorescent light. The aim of this study was to evaluate a modified multicolor ophthalmic OCT device for the detection of early carious lesions in vitro and in vivo. MATERIALS AND METHODS Twenty-seven extracted lesion free human teeth were randomly assigned to three different demineralization protocols. Carious lesion detection was performed using macrophotography, OCT, and reflectance/fluorescence imaging using green laser and blue laser light. In addition, teeth of 5 orthodontic patients were OCT scanned, and fluorescence imaging using blue laser light was performed to assess demineralization after orthodontic therapy. RESULTS Both in vitro and in vivo, OCT allowed for precise determination of lesion depth and enamel loss. Fluorescence imaging using blue laser light was most sensitive for the detection of early demineralization in vitro and in vivo. However, established and severe demineralizations were also reliably detected by macrophotography in vitro and in vivo. CONCLUSION Demineralization can be detected with high sensitivity using blue fluorescence imaging with multicolor OCT devices. CLINICAL RELEVANCE In the future, OCT fluorescence imaging might be considered for longitudinal monitoring of dental hard tissue during orthodontic treatment in clinical trials.

中文翻译：

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使用配备有多色荧光模块的眼科光学相干断层扫描设备在正畸学中进行脱矿质检测。

目的脱矿物质（例如白斑病变）是正畸治疗期间最普遍的副作用之一。荧光设备，包括定量的光诱导荧光（QLF），利用牙釉质和牙齿的固有荧光，最近引入了光学相干断层扫描（OCT），用于早期脱矿质检测。除了近红外OCT扫描外，多色模块还允许使用不同的激光波长成像以及检测反射和荧光。这项研究的目的是评估一种改进的多色眼科OCT设备，用于在体外和体内检测早期龋齿病变。材料与方法将27个提取的无病变人类牙齿随机分配给三种不同的脱矿质方案。使用宏观摄影，OCT以及绿色激光和蓝色激光进行反射/荧光成像来检测龋齿病变。另外，对5名正畸患者的牙齿进行OCT扫描，并使用蓝色激光进行荧光成像以评估正畸治疗后的脱矿质。结果无论是在体内还是体外，OCT均可精确测定病变深度和牙釉质损失。使用蓝激光的荧光成像对于体外和体内早期脱矿质的检测最为敏感。但是，通过宏观摄影术在体外和体内也能可靠地检测到已建立的严重脱盐现象。结论使用多色OCT装置进行蓝色荧光成像可高灵敏度检测脱矿质。临床意义未来，