BACKGROUND This study was designed to detect and assess the frequency and severity of nonmotor symptoms (NMSs) in advanced Parkinson's disease (PD) and to investigate the effects of subthalamic nucleus deep brain stimulation (STN-DBS) on NMSs. METHODS We developed an online PC-based questionnaire program to assess NMSs in PD. Twenty-six PD patients who underwent bilateral STN-DBS were assessed. The NMS questionnaire consisted of 54 NMSs in three categories, based on Witjas et al. (2002). For each NMS, the patients were asked whether or not it was present, whether or not the fluctuating manifestations correlated with the timing of levodopa-induced motor fluctuations, and how severe the NMS was. Patients were assessed by this system before surgery and at the follow-up visit, 3 to 6 months after surgery. At the postoperative assessment, patients were also assessed on preoperative NMSs using recall. RESULTS The most frequent preoperative NMSs were constipation and visual disorders, while the most frequent postoperative NMSs were difficulty in memorizing and pollakiuria. The ranking of most frequent NMSs changed from before to after surgery. NMSs of drenching sweats, dysphagia, and constipation were significantly ameliorated, while NMSs of dyspnea and slowness of thinking were significantly deteriorated after surgery. The preoperative assessment by postoperative recall gave very different results from that of the preoperative assessment. CONCLUSION An online questionnaire system to assess NMSs in patients with advanced PD suggested that STN-DBS might influence the frequencies of some kinds of NMSs.

中文翻译：

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在线调查表程序揭示了慢性丘脑下刺激对晚期帕金森氏病非运动症状的影响。

背景技术本研究旨在检测和评估晚期帕金森病（PD）中非运动症状（NMS）的频率和严重性，并研究丘脑底核深部脑刺激（STN-DBS）对NMS的影响。方法我们开发了一个基于PC的在线问卷调查程序，以评估PD中的NMS。评估了接受双侧STN-DBS治疗的26例PD患者。根据Witjas等人的观点，NMS调查表由三类54个NMS组成。（2002）。对于每个NMS，询问患者是否存在NMS，其波动表现是否与左旋多巴诱发的运动波动的时间相关，以及NMS的严重程度。在手术前以及手术后3至6个月的随访期间，通过该系统对患者进行评估。在术后评估中 还使用召回对患者进行了术前NMS评估。结果术前最常见的NMS为便秘和视觉障碍，而术后最常见的NMS为记忆力和尿频。最常见的NMS的排名从手术前更改为手术后。术后，出汗，吞咽困难和便秘的NMS明显改善，呼吸困难和思维迟缓的NMS术后明显恶化。通过术后召回进行的术前评估与术前评估的结果截然不同。结论在线评估晚期PD患者NMS的在线问卷系统表明，STN-DBS可能会影响某些NMS的频率。结果术前最常见的NMS为便秘和视觉障碍，而术后最常见的NMS为记忆力和尿频。最常见的NMS的排名从手术前更改为手术后。术后，出汗，吞咽困难和便秘的NMS明显改善，呼吸困难和思维迟缓的NMS术后明显恶化。通过术后召回进行的术前评估与术前评估的结果截然不同。结论在线评估晚期PD患者NMS的在线问卷系统表明，STN-DBS可能会影响某些NMS的频率。结果术前最常见的NMS为便秘和视觉障碍，而术后最常见的NMS为记忆困难和尿频。最常见的NMS的排名从手术前更改为手术后。术后，出汗，吞咽困难和便秘的NMS明显改善，呼吸困难和思维迟缓的NMS术后明显恶化。通过术后召回进行的术前评估与术前评估的结果截然不同。结论在线评估晚期PD患者NMS的在线问卷系统表明，STN-DBS可能会影响某些NMS的频率。最常见的NMS的排名从手术前更改为手术后。术后，出汗，吞咽困难和便秘的NMS明显改善，呼吸困难和思维迟缓的NMS术后明显恶化。通过术后召回进行的术前评估与术前评估的结果截然不同。结论在线评估晚期PD患者NMS的在线问卷系统表明，STN-DBS可能会影响某些NMS的频率。最常见的NMS的排名从手术前更改为手术后。术后，出汗，吞咽困难和便秘的NMS明显改善，呼吸困难和思维迟缓的NMS术后明显恶化。通过术后召回进行的术前评估与术前评估的结果截然不同。结论在线评估晚期PD患者NMS的在线问卷系统表明，STN-DBS可能会影响某些NMS的频率。通过术后召回进行的术前评估与术前评估的结果截然不同。结论在线评估晚期PD患者NMS的在线问卷系统表明，STN-DBS可能会影响某些NMS的频率。通过术后召回进行的术前评估与术前评估的结果截然不同。结论在线评估晚期PD患者NMS的在线问卷系统表明，STN-DBS可能会影响某些NMS的频率。