Objective

A phantom for diffusion-weighted imaging is required to standardize quantitative evaluation. The objectives were to develop a phantom simulating various cell densities and to evaluate repeatability.

Materials and methods

The acrylic fine particles with three different diameters were used to simulate human cells. Four-degree cell density components were developed by adjusting the volume of 10-μm particles (5, 20, 35, and 50% volume, respectively). Two-degree components to simulate cell edema were also developed by adjusting the diameter without changing number (17% and 40% volume, respectively). Spearman’s rank correlation coefficient was used to find a significant correlation between apparent diffusion coefficient (ADC) and particle density. Coefficient of variation (CV) for ADC was calculated for each component for 6 months. A p value < 0.05 represented a statistically significance.

Results

Each component (particle ratio of 5, 17, 20, 35, 40, and 50% volume, respectively) presented ADC values of 1.42, 1.30, 1.30, 1.12, 1.09, and 0.89 (× 10⁻³ mm²/s), respectively. A negative correlation (r = − 0.986, p < 0.05) was observed between ADC values and particle ratio. CV for ADC was less than 5%.

Discussion

A phantom simulating the diffusion restriction correlating with cell density and size could be developed.

中文翻译：

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模拟肿瘤细胞生长和细胞水肿的细胞外空间的新模型的开发，用于扩散加权磁共振成像。

目的

需要用于扩散加权成像的体模来标准化定量评估。目的是开发一种模拟各种细胞密度的模型并评估可重复性。

材料和方法

具有三种不同直径的丙烯酸细颗粒用于模拟人体细胞。通过调整10μm颗粒的体积（分别为5％，20％，35％和50％的体积）来开发四度细胞密度成分。还通过调节直径而不改变数量（分别为17％和40％体积）来开发用于模拟细胞水肿的两度成分。Spearman秩相关系数用于发现表观扩散系数（ADC）与颗粒密度之间的显着相关性。为每个组件计算了6个月的ADC变异系数（CV）。甲p值<0.05表示的统计学显着性。

结果

每个成分（分别为5、17、20、35、40和50％体积的颗粒比率）的ADC值分别为1.42、1.30、1.30、1.12、1.09和0.89（×10 ^-3 mm ² / s），分别。 在ADC值和颗粒比之间观察到负相关（r  = − 0.986，p <0.05）。ADC的CV小于5％。

讨论区

可以开发出模拟与细胞密度和大小相关的扩散限制的模型。