Crohn’s disease (CD) is characterized by chronic inflammation of the gastrointestinal tract and represents one of the main inflammatory bowel disease (IBD) forms. The infiltration of immune cells into the mucosa and uncontrolled production of pro-inflammatory cytokines and other mediators trigger the chronic inflammatory reaction in the intestine [1]. The inflammatory setting consists of subsequent events that comprise an induction phase, the peak of inflammation which is subsequently followed by the resolution phase. The induction phase, which represents the first phase of inflammation, is important for the rapid and efficient activation of the immune system for sufficient host defense. The permanent sensing of exogenous or endogenous danger signals enables the fast initiation of the inflammatory reaction. The immune cell infiltrate initiates an inflammatory cascade where released lipid and protein mediators play an indispensable role [2, 3]. The last decades of research strongly suggest that resolution of inflammation is similarly a tightly coordinated and active process. The basic concept that resolution of inflammation has to be regarded as an active process has been thoroughly described by others [4,5,6]. The following review focuses on mechanisms, pathways, and specific mediators that are actively involved in the resolution of inflammation in CD.

中文翻译：

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克罗恩病的解决。

克罗恩病（CD）的特征是胃肠道的慢性炎症，代表主要的炎症性肠病（IBD）形式之一。免疫细胞渗入粘膜，促炎性细胞因子和其他介质的失控产生，引发肠道中的慢性炎症反应[1]。炎性环境包括随后的事件，其包括诱导期，炎症高峰，随后是消融期。诱导期代表炎症的第一阶段，对于免疫系统的快速有效激活以实现足够的宿主防御至关重要。永久感测外源性或内源性危险信号可快速引发炎症反应。免疫细胞浸润引发炎症级联反应，其中释放的脂质和蛋白质介质起着不可或缺的作用[2，3]。最近几十年的研究强烈表明，炎症的消解同样是紧密协调和活跃的过程。其他人已经彻底描述了消炎必须被认为是一个活跃过程的基本概念[4,5,6]。以下评论着重于积极参与CD炎症解决的机制，途径和特定介体。其他人已经彻底描述了消炎必须被认为是一个活跃过程的基本概念[4,5,6]。以下评论着重于积极参与CD炎症解决的机制，途径和特定介体。其他人已经彻底描述了消炎必须被认为是一个活跃过程的基本概念[4,5,6]。以下评论着重于积极参与CD炎症解决的机制，途径和特定介体。