The aim of this study was to ascertain whether long-term occupational exposure to nanoparticles would affect relative leukocyte telomere length (LrTL). We analysed occupational exposure to size-resolved aerosol particles, with special emphasis on nanoparticles at two workshops: i/ the production of nanocomposites containing metal oxides; ii/ laboratory to test experimental exposure of nano-CuO to rodents. Thirty five exposed researchers (age 39.5 ± 12.6 yr; exposure duration 6.0 ± 3.7 yr) and 43 controls (40.4 ± 10.5 yr) were examined. LrTL did not significantly (p=0.14) differ between the exposed researchers (0.92 ± 0.13) and controls (0.86 ± 0.15). In addition, no significant correlation (r=-0.22, p=0.22) was detected between the duration of occupational exposure and LrTL. The results remained non-significant after multiple adjustments for age, sex and smoking status. Our pilot results suggest that relative leukocyte telomere length is not affected by occupational exposure to nanoparticles.

中文翻译：

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白细胞端粒的长度不受纳米金属氧化物长期职业暴露的影响。

这项研究的目的是确定长期职业接触纳米颗粒是否会影响相对白细胞端粒长度（LrTL）。我们在两个研讨会上分析了职业对尺寸分解的气溶胶颗粒的暴露情况，其中特别着重于纳米颗粒：i /含有金属氧化物的纳米复合材料的生产；ii /实验室以测试纳米CuO在啮齿动物中的实验暴露。检查了35位暴露的研究人员（年龄39.5±12.6岁；暴露持续时间6.0±3.7年）和43位对照（40.4±10.5年）。暴露的研究人员（0.92±0.13）和对照组（0.86±0.15）之间的LrTL没有显着差异（p = 0.14）。此外，在职业暴露持续时间和LrTL之间未发现显着相关性（r = -0.22，p = 0.22）。在对年龄进行多次调整后，结果仍然不显着，性别和吸烟状况。我们的初步结果表明，相对于白细胞端粒的长度不受职业性接触纳米颗粒的影响。