Leukocyte telomere length is not affected by long-term occupational exposure          to nano metal oxides

Jaroslav A. HUBACEK; Daniela PELCLOVA; Dana DLOUHA; Pavel MIKUSKA; Stepanka DVORACKOVA; Stepanka VLCKOVA; Zdenka FENCLOVA; Jakub ONDRACEK; Martin KOSTEJN; Jaroslav SCHWARZ; Alex POPOV; Kamil KRUMAL; Vera LANSKA; Pavel COUFALIK; Sergej ZAKHAROV; Vladimir ZDIMAL

doi:10.2486/indhealth.2018-0146

Short Communication

Leukocyte telomere length is not affected by long-term occupational exposure to nano metal oxides

Jaroslav A. HUBACEK, Daniela PELCLOVA, Dana DLOUHA, Pavel MIKUSKA, Stepanka DVORACKOVA, Stepanka VLCKOVA, Zdenka FENCLOVA, Jakub ONDRACEK, Martin KOSTEJN, Jaroslav SCHWARZ, Alex POPOV, Kamil KRUMAL, Vera LANSKA, Pavel COUFALIK, Sergej ZAKHAROV, Vladimir ZDIMAL

Author information

Jaroslav A. HUBACEK
Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Czech Republic
Daniela PELCLOVA
Department of Occupational Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic
Dana DLOUHA
Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Czech Republic
Pavel MIKUSKA
Institute of Analytical Chemistry of the CAS, Czech Republic
Stepanka DVORACKOVA
Department of Machining and Assembly, Department of Engineering Technology, Department of Material Science, Faculty of Mechanical Engineering, Technical University in Liberec, Czech Republic
Stepanka VLCKOVA
Department of Occupational Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic
Zdenka FENCLOVA
Department of Occupational Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic
Jakub ONDRACEK
Institute of Chemical Process Fundamentals CAS, Czech Republic
Martin KOSTEJN
Institute of Chemical Process Fundamentals CAS, Czech Republic
Jaroslav SCHWARZ
Institute of Chemical Process Fundamentals CAS, Czech Republic
Alex POPOV
Department of Machining and Assembly, Department of Engineering Technology, Department of Material Science, Faculty of Mechanical Engineering, Technical University in Liberec, Czech Republic
Kamil KRUMAL
Institute of Analytical Chemistry of the CAS, Czech Republic
Vera LANSKA
Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Czech Republic
Pavel COUFALIK
Institute of Analytical Chemistry of the CAS, Czech Republic
Sergej ZAKHAROV
Department of Occupational Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic
Vladimir ZDIMAL
Institute of Chemical Process Fundamentals CAS, Czech Republic

Keywords: Telomere length, Follow-up, Metal nanoparticles

JOURNAL FREE ACCESS

2019 Volume 57 Issue 6 Pages 741-744

DOI https://doi.org/10.2486/indhealth.2018-0146

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Abstract

The aim of this study was to ascertain whether long-term occupational exposure to nanoparticles would affect relative leukocyte telomere length (LrTL). We analysed occupational exposure to size-resolved aerosol particles, with special emphasis on nanoparticles at two workshops: i/ the production of nanocomposites containing metal oxides; ii/ laboratory to test experimental exposure of nano-CuO to rodents. Thirty five exposed researchers (age 39.5 ± 12.6 yr; exposure duration 6.0 ± 3.7 yr) and 43 controls (40.4 ± 10.5 yr) were examined. LrTL did not significantly (p=0.14) differ between the exposed researchers (0.92 ± 0.13) and controls (0.86 ± 0.15). In addition, no significant correlation (r=−0.22, p=0.22) was detected between the duration of occupational exposure and LrTL. The results remained non-significant after multiple adjustments for age, sex and smoking status. Our pilot results suggest that relative leukocyte telomere length is not affected by occupational exposure to nanoparticles.

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