Abstract

It was shown for the first time that pentaamino acid derivative of fullerene C₆₀ (potassium salt of fullerenylpenta-N-dihydroxytyrosine) affects three targets of type 2 diabetes mellitus. It competitively inhibits the enzymes aldose reductase and sorbitol dehydrogenase and also has an antiglycation effect on bovine serum albumin. The inhibition constants for these enzymes were calculated.

中文翻译：

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富勒烯基戊基-N-二羟基酪氨酸钾盐对2型糖尿病治疗靶点的影响。

摘要

首次表明，富勒烯C _60的五氨基酸衍生物（富勒烯基戊-N-二羟基酪氨酸的钾盐）影响2型糖尿病的三个靶标。它竞争性地抑制醛糖还原酶和山梨糖醇脱氢酶，并且对牛血清白蛋白具有抗糖化作用。计算这些酶的抑制常数。