Skip to main content
SpringerLink
Log in

Potassium Salt of Fullerenylpenta-N-Dihydroxytyrosine Effects on Type 2 Diabetes Mellitus Therapeutic Targets

  • BIOCHEMISTRY, BIOPHYSICS, AND MOLECULAR BIOLOGY
  • Published:
Doklady Biochemistry and Biophysics Aims and scope Submit manuscript

Abstract

It was shown for the first time that pentaamino acid derivative of fullerene C60 (potassium salt of fullerenylpenta-N-dihydroxytyrosine) affects three targets of type 2 diabetes mellitus. It competitively inhibits the enzymes aldose reductase and sorbitol dehydrogenase and also has an antiglycation effect on bovine serum albumin. The inhibition constants for these enzymes were calculated.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.
Fig. 2.
Fig. 3.

Similar content being viewed by others

REFERENCES

  1. World Health Organization, Noncommunicable Diseases Progress Monitor, Geneva: WHO, 2017.

  2. International Diabetes Federation, Diabetes Atlas, 8th ed., Brussels, Belgium, 2017.

  3. World Health Organization. Global Report on Diabetes, Geneva: WHO, 2016.

  4. Yan, L., Anim. Model. Exp. Med., 2018, vol. 1, no. 1, pp. 7–13.

    Article  Google Scholar 

  5. Zheng, H., Wu, J., Jin, Z., et al., Biochem. Insights, 2016, no. 9, pp. 1–9.

  6. Yeh, W.J., Hsia, S.M., Lee, W.H., et al., J. Food Drug Anal., 2017, vol. 25, no. 1, pp. 84–92.

    Article  CAS  Google Scholar 

  7. Jagdale, A.D., Bavkar, L.N., More, T.A., et al., J. Diabetes Complications, 2016, vol. 30, no. 3, pp. 398–405.

    Article  Google Scholar 

  8. Kotel’nikova, R.A., Areshidze, D.A., Soldatova, Yu.V., et al., Application pentaamino acid fullerene derivatives as antioxidants and antidiabetics, RF Patent no. 2669341, Byull. Izobret. no. 28, 2018.

  9. Hosseini, A., Abdollahi, M., Hassanzadeh, G., et al., Basic Clin. Pharmacol. Toxicol., 2011, vol. 109, no. 5, pp. 381–386.

    Article  CAS  Google Scholar 

  10. Nedzvetskii, V.S., Pryshchepa, I.V., Tykhomyrov, A.A., et al., Neurophysiology, 2016, vol. 48, no. 2, pp. 130–140.

    Article  CAS  Google Scholar 

  11. Abdel Motaal, A., El-Askary, H., Crockett, S., et al., Phytomedicine, 2015, vol. 22, no. 9, pp. 829–836.

    Article  CAS  Google Scholar 

  12. Alekseev, V.V., Meditsinskie laboratornye tekhnologii. Rukovodstvo po klinicheskoi laboratornoi diagnostike (Medical Laboratory Technologies. Manual of Clinical Laboratory Diagnostics), Moscow: GEOTAR-Med, 2013.

  13. Berezin, I.V. and Klesov, A.A., Prakticheskii kurs khimicheskoi i fermentativnoi kinetiki (A Practical Course of Chemical and Enzymatic Kinetics), Moscow: Mosk. Univ., 1976.

  14. Chen, Y.F., Roan, H.Y., Lii, C.K., et al., J. Med. Plants Res., 2011, vol. 5, no. 11, pp. 2322–2331.

    Google Scholar 

  15. Saito, R., Tokita, M., Uda, K., et al., Tetrahedron, 2009, vol. 65, no. 15, pp. 3019–3026.

    Article  CAS  Google Scholar 

Download references

Funding

This work was supported by the program of the Presidium of the Russian Academy of Sciences for 2018–2020 “Nanostructures: Physics, Chemistry, Biology, and Basics of Technology” and the State assignment no. 0089-2019-0014. The work on the development of synthesis methods and production of the fullerene derivative were supported by the Russian Science Foundation (project no. 19-13-00411).

Author information

Authors and Affiliations

  1. Institute of Problems of Chemical Physics, Russian Academy of Sciences, 142432, Chernogolovka, Moscow oblast, Russia

    Yu. V. Soldatova, R. A. Kotelnikova, A. V. Zhilenkov, I. I. Faingold, P. A. Troshin, D. A. Areshidze &  S. M. Aldoshin

  2. Moscow Region State University, Moscow, Russia

    Yu. V. Soldatova, I. I. Faingold, M. A. Kozlova & D. A. Areshidze

  3. Skolkovo Institute of Science and Technology, 143025, Moscow, Russia

    P. A. Troshin

Authors
  1. Yu. V. Soldatova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. A. Kotelnikova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. V. Zhilenkov
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. I. I. Faingold
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. P. A. Troshin
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. M. A. Kozlova
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. D. A. Areshidze
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. S. M. Aldoshin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yu. V. Soldatova.

Ethics declarations

Conflict of interests. The authors declare that they have no conflict of interest.

Statement on the welfare of animals. All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.

Additional information

Translated by M. Batrukova

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Soldatova, Y.V., Kotelnikova, R.A., Zhilenkov, A.V. et al. Potassium Salt of Fullerenylpenta-N-Dihydroxytyrosine Effects on Type 2 Diabetes Mellitus Therapeutic Targets. Dokl Biochem Biophys 488, 320–323 (2019). https://doi.org/10.1134/S1607672919050089

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1607672919050089

Search

Navigation