Abstract

A new derivative of 3,7-diazabicyclo[3.3.1]nonane, which showed a high activity as a positive allosteric modulator of AMPA receptors of the CNS, was studied in electrophysiological experiments. At doses of 0.01 mg/kg, this compound significantly improved the memory of experimental animals disturbed by maximal electric shock. The results indicate that this compound is a promising candidate for preclinical trials and clinical studies as a drug for treatment of a number of psychoneurological diseases.

中文翻译：

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AMPA受体的新型正变构调节剂：体外和体内研究。

摘要

在电生理实验中研究了3,7-二氮杂双环[3.3.1]壬烷的新衍生物，该衍生物作为中枢神经系统AMPA受体的正变构调节剂具有很高的活性。在0.01 mg / kg的剂量下，该化合物显着改善了受到最大电击干扰的实验动物的记忆力。结果表明，该化合物作为治疗多种心理神经系统疾病的药物，在临床前试验和临床研究中很有希望。